In Vitro Susceptibility of Clinical Staphylococcus aureus Small-Colony Variants to β-Lactam and Non-β-Lactam Antibiotics

被引：0
|
作者：
Idelevich, Evgeny A. [1 ]
Kriegeskorte, Andre [1 ,2 ]
Schleimer, Nina [1 ]
Peters, Georg [1 ]
von Eiff, Christof [1 ,3 ]
Becker, Karsten [1 ]
机构：
[1] Univ Hosp Munster, Inst Med Microbiol, Munster, Germany
[2] GSK Vaccines GmbH Marburg, Marburg, Germany
[3] Pfizer Pharma GmbH, Berlin, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 04期
关键词：
Staphylococcus aureus; small-colony variants; beta-lactam antibiotics; susceptibility; resistance; aminoglycosides; antibiotic resistance; daptomycin; lincosamides; linezolid; trimethoprim; CYSTIC-FIBROSIS; PHARMACODYNAMIC EVALUATION; INFECTIONS; STRAINS; PERSISTENT; PHENOTYPE; MODEL;
D O I：
10.1128/AAC.02532-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The Staphylococcus aureus small-colony variant (SCV) phenotype has been associated with relapsing and antibiotic-refractory infections. However, little is known about the activities of antibiotics on clinical SCVs. Here, we demonstrated that SCVs without detectable auxotrophies were at least as susceptible to most beta-lactam and non-beta-lactam antibiotics in vitro as their corresponding clonally identical strains with a normal phenotype. After prolonged incubation, a regrowth phenomenon has been observed in gradient diffusion inhibition zones irrespective of the strains' phenotype.
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页数：5
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