In Vitro Susceptibility of Clinical Staphylococcus aureus Small-Colony Variants to β-Lactam and Non-β-Lactam Antibiotics

被引：0

作者：

Idelevich, Evgeny A. ^{[1
]}

Kriegeskorte, Andre ^{[1
,2
]}

Schleimer, Nina ^{[1
]}

Peters, Georg ^{[1
]}

von Eiff, Christof ^{[1
,3
]}

Becker, Karsten ^{[1
]}

机构：

[1] Univ Hosp Munster, Inst Med Microbiol, Munster, Germany

[2] GSK Vaccines GmbH Marburg, Marburg, Germany

[3] Pfizer Pharma GmbH, Berlin, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 04期

关键词：

Staphylococcus aureus; small-colony variants; beta-lactam antibiotics; susceptibility; resistance; aminoglycosides; antibiotic resistance; daptomycin; lincosamides; linezolid; trimethoprim; CYSTIC-FIBROSIS; PHARMACODYNAMIC EVALUATION; INFECTIONS; STRAINS; PERSISTENT; PHENOTYPE; MODEL;

D O I：

10.1128/AAC.02532-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Staphylococcus aureus small-colony variant (SCV) phenotype has been associated with relapsing and antibiotic-refractory infections. However, little is known about the activities of antibiotics on clinical SCVs. Here, we demonstrated that SCVs without detectable auxotrophies were at least as susceptible to most beta-lactam and non-beta-lactam antibiotics in vitro as their corresponding clonally identical strains with a normal phenotype. After prolonged incubation, a regrowth phenomenon has been observed in gradient diffusion inhibition zones irrespective of the strains' phenotype.

引用

页数：5

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