Alkaloids and styryllactones from the leaves of Goniothalamus tamirensis

被引：19

作者：

Dang Thach Tran ^{[1
,3
]}

Huong Doan Thi Mai ^{[1
]}

Van Cuong Pham ^{[1
]}

Van Hung Nguyen ^{[1
]}

Litaudon, Marc ^{[2
]}

Gueritte, Franoise ^{[2
]}

Quoc Vuong Nguyen ^{[1
]}

Tuan Anh Tran ^{[1
]}

Van Minh Chau ^{[1
]}

机构：

[1] Vietnam Acad Sci & Technol, Inst Marine Biochem, Hanoi, Vietnam

[2] CNRS, Inst Chim Subst Nat, F-91190 Gif Sur Yvette, France

[3] Univ Vinh, Vinh, Vietnam

来源：

PHYTOCHEMISTRY LETTERS | 2013年 / 6卷 / 01期

关键词：

Annonaceae; Goniothalamus tamirensis; Alkaloid; Styrylactone; Gonitamirine; Goniotamiric acid; 3,5-Demethoxypiperolide; Cytotoxicity; MTPA MOSHER AMIDES; ANNONACEAE; ASSIGNMENT; PLANTS;

D O I：

10.1016/j.phytol.2012.10.015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new compounds, goniotamirine (1), goniotamiric acid (2), and 3,5-demethoxypiperolide (3) were isolated from the leaves of Goniothalamus tamirensis (Annonaceae), together with sixteen known compounds, (-)-N-nornuciferine (4), (-)-norisocorydine (5), (-)-isocorydine (6), (-)-3-hydroxynornuceferine (7), (-)-O-methylisopiline (8), (-)-anonaine (9), (-)-roemerine (10), (-)-roemeroline (11), (-)-boldine (12), glaunine (13), liriodenine (14), 9-deoxygoniopypyrone (15), 8-epi-9-deoxygoniopypyrone (16), 8-epi-9-deoxygoniopypyrone acetate (17), goniodiol (18) and goniothalamin (19). The structures were established from spectral analysis, including mass spectrometry and 2D-NMR. The absolute configuration of 1 was determined from analysis of its MTPA amide derivatives. The cytotoxicity of all isolates was evaluated against KB cells. Only compound 4 (N-nornuciferine) showed a moderate activity with an IC50 value of 12 mu g/mL. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.

引用

页码：79 / 83

页数：5

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