GD3-replica peptides selected from a phage peptide library induce a GD3 ganglioside antibody response

被引：15
|
作者：
Popa, I
Ishikawa, D
Tanaka, M
Ogino, K
Portoukalian, J
Taki, T
机构：
[1] Otsuka Pharmaceut Co Ltd, Mol Med Sci Inst, Tokushima 7710192, Japan
[2] Hop Edouard Herriot, INSERM U346, Lyon, France
[3] Inst Mol Chem Petru Poni, Iasi, Romania
来源：
FEBS LETTERS | 2006年 / 580卷 / 05期
关键词：
GD3-replica peptide; antibody response; antigen presentation;
D O I：
10.1016/j.febslet.2006.01.063
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
GD3-replica peptides were obtained from a phage peptide library and an anti-GD3 monoclonal antibody (Mab) (4F6), and anti-GD3 Mabs were generated by immunizing a peptide GD3P4. A Mab, 3132 was found to recognize GD3 by immunohistochemical approaches. Amino acid analysis of heavy and light chain variable regions of 4F6 and 3132 showed that the respective chains had the same length, and only a few different amino acid substitutions were found. The present data indicate that the immunogenic GD3P4 is processed in a certain size and exposed on the antigen-presenting cells with a molecular shape quite similar to that of the GD3 epitope in 4F6. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1398 / 1404
页数：7
相关论文
共 50 条
  • [1] Biological properties of replica peptides of GD3 ganglioside
    Popa, I
    Ishikawa, D
    Lazar, A
    Haftek, M
    Coleman, A
    Schmitt, D
    Portoukalian, J
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (06) : A103 - A103
  • [2] Molecular mimicry of phage displayed peptides mimicking GD3 ganglioside
    Willers, J
    Lucchese, A
    Kanduc, D
    Ferrone, S
    PEPTIDES, 1999, 20 (09) : 1021 - 1026
  • [3] Antibody response to GD3 ganglioside is independent of NKT cells
    Park, J-E
    Lu, S. X.
    Wu, D. Y.
    Prendes, M.
    Chapman, P. B.
    CYTOTHERAPY, 2008, 10 (01) : 38 - 44
  • [4] GD3/PROTEOSOME VACCINES INDUCE CONSISTENT IGM ANTIBODIES AGAINST THE GANGLIOSIDE GD3
    LIVINGSTON, PO
    CALVES, MJ
    HELLING, F
    ZOLLINGER, WD
    BLAKE, MS
    LOWELL, GH
    VACCINE, 1993, 11 (12) : 1199 - 1204
  • [5] Compared immunogenicity in mice of GD3 ganglioside purified from human malignant melanoma versus glyco-replica peptides mimicking GD3
    Popa, I
    Ishikawa, D
    Taki, T
    Portoukalian, J
    Thomas, L
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2000, 115 (03) : 521 - 521
  • [6] ANTIBODY-RESPONSE TO IMMUNIZATION WITH PURIFIED GD3 GANGLIOSIDE AND GD3 DERIVATIVES (LACTONES, AMIDE AND GANGLIOSIDOL) IN THE MOUSE
    RITTER, G
    BOOSFELD, E
    CALVES, MJ
    OETTGEN, HF
    OLD, LJ
    LIVINGSTON, PO
    IMMUNOBIOLOGY, 1990, 182 (01) : 32 - 43
  • [7] GD3 ganglioside and apoptosis
    Malisan, F
    Testi, R
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2002, 1585 (2-3): : 179 - 187
  • [8] ANTIBODY-RESPONSE TO IMMUNIZATION WITH GANGLIOSIDE GD3 AND GD3 CONGENERS (LACTONES, AMIDE AND GANGLIOSIDOL) IN PATIENTS WITH MALIGNANT-MELANOMA
    RITTER, G
    BOOSFELD, E
    ADLURI, R
    CALVES, M
    OETTGEN, HF
    OLD, LJ
    LIVINGSTON, P
    INTERNATIONAL JOURNAL OF CANCER, 1991, 48 (03) : 379 - 385
  • [9] Sequential immunization of melanoma patients with GD3 ganglioside vaccine and anti-idiotypic monoclonal antibody that mimics GD3 ganglioside
    Chapman, PB
    Wu, D
    Ragupathi, G
    Lu, S
    Williams, L
    Hwu, WJ
    Johnson, D
    Livingston, PO
    CLINICAL CANCER RESEARCH, 2004, 10 (14) : 4717 - 4723
  • [10] SYNTHETIC STUDIES ON GANGLIOSIDE GD3
    SHIMIZU, C
    IKEDA, K
    ACHIWA, K
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1987, 76 (11) : S172 - S172
12345