SYNTHESIS OF HIGHLY OXYGENATED BIPHENYL DERIVATIVE IN AN OPTICALLY ACTIVE FORM THROUGH PALLADIUM-MEDIATED INTRAMOLECULAR BIARYL COUPLING REACTION

被引：6

作者：

Abe, Hitoshi ^{[1
]}

Arai, Masatsugu ^{[2
]}

Nishioka, Keisuke ^{[2
]}

Kida, Tatsuya ^{[2
]}

Shioe, Kazuma ^{[2
]}

Takeuchi, Yasuo ^{[2
]}

Harayama, Takashi ^{[3
]}

机构：

[1] Okayama Univ, Adv Sci Res Ctr, Okayama 7008530, Japan

[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008530, Japan

[3] Tokushima Bunri Univ, Fac Pharmaceut Sci Kagawa Campus, Sanuki, Kagawa 7692193, Japan

来源：

HETEROCYCLES | 2008年 / 76卷 / 01期

关键词：

Palladium; Axial Chirality; Lactone; Enantioselective Reduction; Biaryl;

D O I：

10.3987/COM-08-S(N)8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically active 6,6'-dihydroxyniethyl-2,2'-3,3'-4,4'-hexamethoxybiphenyl (1) was prepared via the Pd-mediated biaryl coupling reaction of a phenyl benzoate derivative and the following enantioselective lactone opening reaction.

引用

页码：291 / 303

页数：13

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