RUNX family: Regulation and diversification of roles through interacting proteins

被引：161

作者：

Chuang, Linda Shyue Huey ^{[1
]}

Ito, Kosei ^{[2
]}

Ito, Yoshiaki ^{[1
,3
]}

机构：

[1] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117599, Singapore

[2] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 852, Japan

[3] Inst Mol & Cell Biol, Proteos, Singapore

来源：

INTERNATIONAL JOURNAL OF CANCER | 2013年 / 132卷 / 06期

关键词：

RUNX; signaling pathways; tumor suppressor; interacting proteins; post-translational modification; CORE-BINDING-FACTOR; PIM-1 KINASE PHOSPHORYLATES; GASTRIC EPITHELIAL-CELLS; TUMOR-SUPPRESSOR RUNX3; REMODELING GENE ARID1A; TGF-BETA SUPERFAMILY; E3 UBIQUITIN LIGASE; TRANSCRIPTION FACTOR; BREAST-CANCER; AML1-MEDIATED TRANSCRIPTION;

D O I：

10.1002/ijc.27964

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Runt-related transcription factors (RUNX) belong to an ancient family of metazoan genes involved in developmental processes. Through multiple protein-interacting partners, RUNX proteins have been implicated in diverse signaling pathways and cellular processes. The frequent inactivation of RUNX genes in cancer indicates crucial roles for RUNX in tumor suppression. This review discusses the abilities of RUNX proteins, in particular RUNX3, to integrate oncogenic signals or environmental cues and to initiate appropriate tumor suppressive responses.

引用

页码：1260 / 1271

页数：12

共 162 条

[1] LATS2-Ajuba complex regulates γ-tubulin recruitment to centrosomes and spindle organization during mitosis [J].

Abe, Y ;

Ohsugi, M ;

Haraguchi, K ;

Fujimoto, J ;

Yamamoto, T .

FEBS LETTERS, 2006, 580 (03) :782-788

[2] Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity [J].

Aho, Teija L. T. ;

Sandholm, Jouko ;

Peltola, Katriina J. ;

Ito, Yoshiaki ;

Koskinen, Paivi J. .

BMC CELL BIOLOGY, 2006, 7 (1)

[3] Roles of HIPK1 and HIPK2 in AML1-and p300-dependent transcription, hematopoiesis and blood vessel formation [J].

Aikawa, Yukiko ;

Nguyen, Lan Anh ;

Isono, Kyoichi ;

Takakura, Nobuyuki ;

Tagata, Yusuke ;

Schmitz, M. Lienhard ;

Koseki, Haruhiko ;

Kitabayashi, Issay .

EMBO JOURNAL, 2006, 25 (17) :3955-3965

[4] TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation [J].

Alliston, T ;

Choy, L ;

Ducy, P ;

Karsenty, G ;

Derynck, R .

EMBO JOURNAL, 2001, 20 (09) :2254-2272

[5] Tumor Necrosis Factor Receptor-associated Factor 6 Is an Intranuclear Transcriptional Coactivator in Osteoclasts [J].

Bai, Shuting ;

Zha, Jikun ;

Zhao, Haibo ;

Ross, F. Patrick ;

Teitelbaum, Steven L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (45) :30861-30867

[6] The Human SWI/SNF Complex Associates With RUNX1 to Control Transcription of Hematopoietic Target Genes [J].

Bakshi, Rachit ;

Hassan, Mohammad Q. ;

Pratap, Jitesh ;

Lian, Jane B. ;

Montecino, Martin A. ;

van Wijnen, Andre J. ;

Stein, Janet L. ;

Imbalzano, Anthony N. ;

Stein, Gary S. .

JOURNAL OF CELLULAR PHYSIOLOGY, 2010, 225 (02) :569-576

[7] Sequence analysis of mutations and translocations across breast cancer subtypes [J].

Banerji, Shantanu ;

Cibulskis, Kristian ;

Rangel-Escareno, Claudia ;

Brown, Kristin K. ;

Carter, Scott L. ;

Frederick, Abbie M. ;

Lawrence, Michael S. ;

Sivachenko, Andrey Y. ;

Sougnez, Carrie ;

Zou, Lihua ;

Cortes, Maria L. ;

Fernandez-Lopez, Juan C. ;

Peng, Shouyong ;

Ardlie, Kristin G. ;

Auclair, Daniel ;

Bautista-Pina, Veronica ;

Duke, Fujiko ;

Francis, Joshua ;

Jung, Joonil ;

Maffuz-Aziz, Antonio ;

Onofrio, Robert C. ;

Parkin, Melissa ;

Pho, Nam H. ;

Quintanar-Jurado, Valeria ;

Ramos, Alex H. ;

Rebollar-Vega, Rosa ;

Rodriguez-Cuevas, Sergio ;

Romero-Cordoba, Sandra L. ;

Schumacher, Steven E. ;

Stransky, Nicolas ;

Thompson, Kristin M. ;

Uribe-Figueroa, Laura ;

Baselga, Jose ;

Beroukhim, Rameen ;

Polyak, Kornelia ;

Sgroi, Dennis C. ;

Richardson, Andrea L. ;

Jimenez-Sanchez, Gerardo ;

Lander, Eric S. ;

Gabriel, Stacey B. ;

Garraway, Levi A. ;

Golub, Todd R. ;

Melendez-Zajgla, Jorge ;

Toker, Alex ;

Getz, Gad ;

Hidalgo-Miranda, Alfredo ;

Meyerson, Matthew .

NATURE, 2012, 486 (7403) :405-409

[8] AML1 stimulates G1 to S progression via its transactivation domain [J].

Bernardin, F ;

Friedman, AD .

ONCOGENE, 2002, 21 (20) :3247-3252

[9] AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression [J].

Bernardin-Fried, F ;

Kummalue, T ;

Leijen, S ;

Collector, MI ;

Ravid, K ;

Friedman, AD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (15) :15678-15687

[10]

BIECHE I, 1993, CANCER RES, V53, P1990

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