O-GlcNAcylation in Renal (Patho)Physiology

被引：10

作者：

Silva-Aguiar, Rodrigo P. ^{[1
]}

Peruchetti, Diogo B. ^{[1
]}

Pinheiro, Ana Acacia S. ^{[1
,2
]}

Caruso-Neves, Celso ^{[1
,2
,3
]}

Dias, Wagner B. ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Carlos Chagas Filho Inst Biophys, BR-21941901 Rio De Janeiro, Brazil

[2] Rio de Janeiro Innovat Network Nanosyst Hlth Nano, BR-21045900 Rio De Janeiro, Brazil

[3] Natl Inst Sci & Technol Regenerat Med, BR-21941902 Rio De Janeiro, Brazil

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 19期

关键词：

O-GlcNAcylation; kidney; renal disease; albuminuria; post-translational modification; O-GlcNAc transferase; O-GlcNAcase; O-GlcNAc; N-ACETYLGLUCOSAMINE TRANSFERASE; ACUTE KIDNEY INJURY; GLCNAC TRANSFERASE; HIGH GLUCOSE; HEXOSAMINE BIOSYNTHESIS; PROTEINURIA REDUCTION; TRAUMA-HEMORRHAGE; CARDIAC-FUNCTION; CROSS-TALK; STRESS;

D O I：

10.3390/ijms231911260

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kidneys maintain internal milieu homeostasis through a well-regulated manipulation of body fluid composition. This task is performed by the correlation between structure and function in the nephron. Kidney diseases are chronic conditions impacting healthcare programs globally, and despite efforts, therapeutic options for its treatment are limited. The development of chronic degenerative diseases is associated with changes in protein O-GlcNAcylation, a post-translation modification involved in the regulation of diverse cell function. O-GlcNAcylation is regulated by the enzymatic balance between O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) which add and remove GlcNAc residues on target proteins, respectively. Furthermore, the hexosamine biosynthetic pathway provides the substrate for protein O-GlcNAcylation. Beyond its physiological role, several reports indicate the participation of protein O-GlcNAcylation in cardiovascular, neurodegenerative, and metabolic diseases. In this review, we discuss the impact of protein O-GlcNAcylation on physiological renal function, disease conditions, and possible future directions in the field.

引用

页数：15

共 163 条

[71] O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease [J].

Liu, F ;

Iqbal, K ;

Grundke-Iqbal, I ;

Hart, GW ;

Gong, CX .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (29) :10804-10809

[72] Increased hexosamine biosynthesis and protein O-GlcNAc levels associated with myocardial protection against calcium paradox and ischemia [J].

Liu, J ;

Pang, Y ;

Chang, T ;

Bounelis, P ;

Chatham, JC ;

Marchase, RB .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2006, 40 (02) :303-312

[73] Urinary proteins induce lysosomal membrane permeabilization and lysosomal dysfunction in renal tubular epithelial cells [J].

Liu, Wei Jing ;

Xu, Bi-Hua ;

Ye, Lin ;

Liang, Dong ;

Wu, Hong-Luan ;

Zheng, Yuan-Yuan ;

Deng, Jian Kun ;

Li, Benyi ;

Liu, Hua-feng .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2015, 308 (06) :F639-F649

[74] O-GlcNAc elevation through activation of the hexosamine biosynthetic pathway enhances cancer cell chemoresistance [J].

Liu, Yubo ;

Cao, Yu ;

Pan, Xiaoqing ;

Shi, Meiyun ;

Wu, Qiong ;

Huang, Tianmiao ;

Jiang, Hui ;

Li, Wenli ;

Zhang, Jianing .

CELL DEATH & DISEASE, 2018, 9

[75] O-GlcNAc cycling: Emerging roles in development and epigenetics [J].

Love, Dona C. ;

Krause, Michael W. ;

Hanover, John A. .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2010, 21 (06) :646-654

[76] Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation [J].

Lucena, Miguel C. ;

Carvalho-Cruz, Patricia ;

Donadio, Joana L. ;

Oliveira, Isadora A. ;

de Queiroz, Rafaela M. ;

Marinho-Carvalho, Monica M. ;

Sola-Penna, Mauro ;

de Paula, Iron F. ;

Gondim, Katia C. ;

McComb, Mark E. ;

Costello, Catherine E. ;

Whelan, Stephen A. ;

Todeschini, Adriane R. ;

Dias, Wagner B. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (25) :12917-12929

[77] Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure [J].

Lunde, Ida G. ;

Aronsen, Jan Magnus ;

Kvaloy, Heidi ;

Qvigstad, Eirik ;

Sjaastad, Ivar ;

Tonnessen, Theis ;

Christensen, Geir ;

Gronning-Wang, Line M. ;

Carlson, Cathrine R. .

PHYSIOLOGICAL GENOMICS, 2012, 44 (02) :162-172

[78] Demystifying the O-GlcNAc Code: A Systems View [J].

Ma, Junfeng ;

Hou, Chunyan ;

Wu, Ci .

CHEMICAL REVIEWS, 2022, 122 (20) :15822-15864

[79] Protein O-GlcNAcylation in diabetes and diabetic complications [J].

Ma, Junfeng ;

Hart, Gerald W. .

EXPERT REVIEW OF PROTEOMICS, 2013, 10 (04) :365-380

[80] The emerging link between O-GlcNAcylation and neurological disorders [J].

Ma, Xiaofeng ;

Li, He ;

He, Yating ;

Hao, Junwei .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2017, 74 (20) :3667-3686

← 3 4 5 6 7 8 9 10 11 12 →