O-GlcNAcylation in Renal (Patho)Physiology

被引：10

作者：

Silva-Aguiar, Rodrigo P. ^{[1
]}

Peruchetti, Diogo B. ^{[1
]}

Pinheiro, Ana Acacia S. ^{[1
,2
]}

Caruso-Neves, Celso ^{[1
,2
,3
]}

Dias, Wagner B. ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Carlos Chagas Filho Inst Biophys, BR-21941901 Rio De Janeiro, Brazil

[2] Rio de Janeiro Innovat Network Nanosyst Hlth Nano, BR-21045900 Rio De Janeiro, Brazil

[3] Natl Inst Sci & Technol Regenerat Med, BR-21941902 Rio De Janeiro, Brazil

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 19期

关键词：

O-GlcNAcylation; kidney; renal disease; albuminuria; post-translational modification; O-GlcNAc transferase; O-GlcNAcase; O-GlcNAc; N-ACETYLGLUCOSAMINE TRANSFERASE; ACUTE KIDNEY INJURY; GLCNAC TRANSFERASE; HIGH GLUCOSE; HEXOSAMINE BIOSYNTHESIS; PROTEINURIA REDUCTION; TRAUMA-HEMORRHAGE; CARDIAC-FUNCTION; CROSS-TALK; STRESS;

D O I：

10.3390/ijms231911260

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kidneys maintain internal milieu homeostasis through a well-regulated manipulation of body fluid composition. This task is performed by the correlation between structure and function in the nephron. Kidney diseases are chronic conditions impacting healthcare programs globally, and despite efforts, therapeutic options for its treatment are limited. The development of chronic degenerative diseases is associated with changes in protein O-GlcNAcylation, a post-translation modification involved in the regulation of diverse cell function. O-GlcNAcylation is regulated by the enzymatic balance between O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) which add and remove GlcNAc residues on target proteins, respectively. Furthermore, the hexosamine biosynthetic pathway provides the substrate for protein O-GlcNAcylation. Beyond its physiological role, several reports indicate the participation of protein O-GlcNAcylation in cardiovascular, neurodegenerative, and metabolic diseases. In this review, we discuss the impact of protein O-GlcNAcylation on physiological renal function, disease conditions, and possible future directions in the field.

引用

页数：15

共 163 条

[1] Blocked O-GlcNAc cycling disrupts mouse hematopoeitic stem cell maintenance and early T cell development [J].

Abramowitz, Lara K. ;

Harly, Christelle ;

Das, Arundhoti ;

Bhandoola, Avinash ;

Hanover, John A. .

SCIENTIFIC REPORTS, 2019, 9 (1)

[2] Nutrient-driven O-GlcNAc in proteostasis and neurodegeneration [J].

Akan, Ilhan ;

Stichelen, Stephanie Olivier-Van ;

Bond, Michelle R. ;

Hanover, John A. .

JOURNAL OF NEUROCHEMISTRY, 2018, 144 (01) :7-34

[3] Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer [J].

Akella, Neha M. ;

Ciraku, Lorela ;

Reginato, Mauricio J. .

BMC BIOLOGY, 2019, 17 (1)

[4] Diabetic Kidney Disease Challenges, Progress, and Possibilities [J].

Alicic, Radica Z. ;

Rooney, Michele T. ;

Tuttle, Katherine R. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2017, 12 (12) :2032-2045

[5] Chemical Modulation of Protein O-GIcNAcylation via OGT Inhibition Promotes Human Neural Cell Differentiation [J].

Andres, Lissette M. ;

Blong, Ian W. ;

Evans, Angela C. ;

Rumachik, Neil G. ;

Yamaguchi, Teppei ;

Pham, Nam D. ;

Thompson, Pamela ;

Kohler, Jennifer J. ;

Bertozzi, Carolyn R. .

ACS CHEMICAL BIOLOGY, 2017, 12 (08) :2030-2039

[6] The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy [J].

Ardito, Fatima ;

Giuliani, Michele ;

Perrone, Donatella ;

Troiano, Giuseppe ;

Lo Muzio, Lorenzo .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2017, 40 (02) :271-280

[7] Diabetes-associated dysregulation of O-GlcNAcylation in rat cardiac mitochondria [J].

Banerjee, Partha S. ;

Ma, Junfeng ;

Hart, Gerald W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (19) :6050-6055

[8]

Baudoin L, 2015, FRONT ENDOCRINOL, V5, DOI [10.3389/fendo.2016.00235, 10.3389/fendo.2014.00235]

[9] Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 [J].

Bikbov, Boris ;

Purcell, Carrie ;

Levey, Andrew S. ;

Smith, Mari ;

Abdoli, Amir ;

Abebe, Molla ;

Adebayo, Oladimeji M. ;

Afarideh, Mohsen ;

Agarwal, Sanjay Kumar ;

Agudelo-Botero, Marcela ;

Ahmadian, Elham ;

Al-Aly, Ziyad ;

Alipour, Vahid ;

Almasi-Hashiani, Amir ;

Al-Raddadi, Rajaa M. ;

Alvis-Guzman, Nelson ;

Amini, Saeed ;

Andrei, Tudorel ;

Andrei, Catalina Liliana ;

Andualem, Zewudu ;

Anjomshoa, Mina ;

Arabloo, Jalal ;

Ashagre, Alebachew Fasil ;

Asmelash, Daniel ;

Ataro, Zerihun ;

Atout, Maha Moh'd Wahbi ;

Ayanore, Martin Amogre ;

Badawi, Alaa ;

Bakhtiari, Ahad ;

Ballew, Shoshana H. ;

Balouchi, Abbas ;

Banach, Maciej ;

Barquera, Simon ;

Basu, Sanjay ;

Bayih, Mulat Tirfie ;

Bedi, Neeraj ;

Bello, Aminu K. ;

Bensenor, Isabela M. ;

Bijani, Ali ;

Boloor, Archith ;

Borzi, Antonio M. ;

Camera, Luis Alberto ;

Carrero, Juan J. ;

Carvalho, Felix ;

Castro, Franz ;

Catala-Lopez, Ferran ;

Chang, Alex R. ;

Chin, Ken Lee ;

Chung, Sheng-Chia ;

Cirillo, Massimo .

LANCET, 2020, 395 (10225) :709-733

[10] The Many Ways by Which O-GlcNAcylation May Orchestrate the Diversity of Complex Glycosylations [J].

Biwi, James ;

Biot, Christophe ;

Guerardel, Yann ;

Vercoutter-Edouart, Anne-Sophie ;

Lefebvre, Tony .

MOLECULES, 2018, 23 (11)

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