Molecular subclasses of breast cancer: how do we define them? The IMPAKT 2012 Working Group Statement

被引：220

作者：

Guiu, S. ^{[2
]}

Michiels, S. ^{[3
]}

Andre, F. ^{[1
]}

Cortes, J. ^{[4
]}

Denkert, C. ^{[5
]}

Di Leo, A. ^{[6
]}

Hennessy, B. T. ^{[7
]}

Sorlie, T. ^{[8
]}

Sotiriou, C. ^{[9
]}

Turner, N. ^{[10
]}

Van de Vijver, M. ^{[11
]}

Viale, G. ^{[12
]}

Loi, S. ^{[13
]}

Reis-Filho, J. S. ^{[14
]}

机构：

[1] Inst Gustave Roussy, INSERM Unit, Dept Med Oncol, U981, F-94805 Villejuif, France

[2] Georges Francois Leclerc Canc Ctr, Dept Med Oncol, Dijon, France

[3] Inst Jules Bordet, Dept Biostat & Epidemiol, B-1000 Brussels, Belgium

[4] Vall dHebron Inst Oncol, Dept Oncol, Barcelona, Spain

[5] Charite, Inst Pathol, D-13353 Berlin, Germany

[6] Hosp Prato, Ist Toscani Tumori, Med Oncol Unit, Prato, Italy

[7] Beaumont Hosp, Dept Med Oncol, Dublin 9, Ireland

[8] Norwegian Radium Hosp, Oslo Univ Hosp, Inst Canc Res, Dept Genet, Oslo, Norway

[9] Inst Jules Bordet, Ctr Tumeurs, B-1000 Brussels, Belgium

[10] Royal Marsden Fdn Trust, Inst Canc Res, London, England

[11] Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands

[12] Univ Milan, European Inst Oncol, Milan, Italy

[13] Inst Jules Bordet, Dept Translat Res, Breast Canc Translat Res Lab, B-1000 Brussels, Belgium

[14] Inst Canc Res, Breakthrough Breast Canc Res, London SW3 6JB, England

来源：

ANNALS OF ONCOLOGY | 2012年 / 23卷 / 12期

关键词：

breast cancer; Ki-67; molecular classification; molecular subclasses; PAM50; PATHOLOGISTS GUIDELINE RECOMMENDATIONS; ESTROGEN-RECEPTOR; AMERICAN-SOCIETY; PROGNOSTIC VALUE; TUMOR SUBTYPES; CLASSIFICATION; IDENTIFICATION; MICROARRAY; RISK; CHEMOTHERAPY;

D O I：

10.1093/annonc/mds586

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The 2012 IMPAKT task force investigated the medical usefulness of current methods for the classification of breast cancer into the 'intrinsic' molecular subtypes (luminal A, luminal B, basal-like and HER2). A panel of breast cancer and/or gene expression profiling experts evaluated the analytical validity, clinical validity and clinical utility of two approaches for molecular subtyping of breast cancer: the prediction analysis of microarray (PAM)50 assay and an immuno-histochemical (IHC) surrogate panel including oestrogen receptor (ER), HER2 and Ki67. The panel found the currently available evidence on the analytical validity and clinical utility of Ki67 based on a 14% cut-off and PAM50 to be inadequate. The majority of the working group members found the available evidence on the analytical validity, clinical validity and clinical utility of ER/HER2 to be convincing. The panel concluded that breast cancer classification into molecular subtypes based on the IHC assessment of ER, HER2 and Ki67 with a 14% cut-off and on the PAM50 test does not provide sufficiently robust information to modify systemic treatment decisions, and recommended the use IHC for ER and HER2 for the identification of clinically relevant subtypes of breast cancers. Methods for breast cancer classification into molecular subtypes should, however, be incorporated into clinical trial design.

引用

页码：2997 / 3006

页数：10

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