CHEMICAL CONSTITUENTS OF Capraria biflora (SCROPHULARIACEAE) AND LARVICIDAL ACTIVITY OF ESSENTIAL OIL

被引：20

作者：

Souza, Luciana Gregorio da S. ^{[1
]}

Almeida, Macia Cleane S. ^{[1
]}

Monte, Francisco Jose Q. ^{[1
]}

Santiago, Gilvandete Maria P. ^{[1
]}

Braz-Filho, Raimundo ^{[1
]}

Lemos, Telma Leda G. ^{[1
]}

Gomes, Clerton L. ^{[2
]}

do Nascimento, Ronaldo F. ^{[2
]}

机构：

[1] Univ Fed Ceara, Dept Quim Organ & Inorgan, BR-60451970 Fortaleza, CE, Brazil

[2] Univ Fed Ceara, Ctr Cencias, Dept Quim Analit & Fis Quim, BR-60451970 Fortaleza, CE, Brazil

来源：

QUIMICA NOVA | 2012年 / 35卷 / 11期

关键词：

chlorinated iridoid; Capraria biflora; essential oil; LEAVES;

D O I：

10.1590/S0100-40422012001100032

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

CHEMICAL CONSTITUENTS OF Capraria biflora (SCROPHULARIACEAE) AND LARVICIDAL ACTIVITY OF ESSENTIAL OIL. Analysis of essential oil from fresh leaves of Capraria biflora allowed identification of fourteen essential oil constituents among which thirteen are sesquiterpene compounds, and alpha-humulene (43.0%) the major constituent. The essential oil was tested for larvicidal activity against Aedes aegypti showing good activity, with LC50 73.39 mu g/mL (2.27 g/mL). Chromatographic studies of extracts from roots and stems allowed the isolation of five compounds: naphthoquinone biflorin, sesquiterpene caprariolide B, the steroid beta-sitosterol, the carbohydrate D-mannitol and iridoid myopochlorin first reported in the species C. biflora. The structures of compounds were characterized by spectroscopic data, IR, MS, (NMRC)-C-13, (NMRH)-H-1, NOE, HSQC and HMBC.

引用

页码：2258 / 2262

页数：5

共 22 条

[1] Analgesic properties of Capraria biflora leaves aqueous extract [J].

Acosta, SL ;

Muro, LV ;

Sacerio, AL ;

Peña, AR ;

Okwei, SN .

FITOTERAPIA, 2003, 74 (7-8) :686-688

[2]

Adams R., 2007, IDENTIFICATION ESSEN

[3]

Aquino T. M., 2003, THESIS U FEDERAL PER

[4]

Aquino TM, 2006, ACTA FARM BONAER, V25, P460

[5] Bioactivity of selected plant essential oils against the yellow fever mosquito Aedes aegypti larvae [J].

Cheng, SS ;

Chang, HT ;

Chang, ST ;

Tsai, KH ;

Chen, WJ .

BIORESOURCE TECHNOLOGY, 2003, 89 (01) :99-102

[6] New skeletal sesquiterpenoids, caprariolides A-D, from Capraria biflora and their insecticidal activity [J].

Collins, DO ;

Gallimore, WA ;

Reynolds, WF ;

Williams, LAD ;

Reese, PB .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (11) :1515-1518

[7] FLAVONOIDS AND OTHER SUBSTANCES FROM Lippia sidoides AND THEIR ANTIOXIDANT ACTIVITIES [J].

de Almeida, Macia Cleane S. ;

Alves, Leonardo A. ;

Souza, Luciana Gregorio da S. ;

Machado, Luciana L. ;

de Matos, Marcos C. ;

de Oliveira, Maria Conceicao F. ;

Lemos, Telma L. G. ;

Braz Filho, Raimundo .

QUIMICA NOVA, 2010, 33 (09) :1877-1881

[8] Antitumor activity of biflorin, an o-naphthoquinone isolated from Capraria biflora [J].

de Vasconcellos, Marne Carvalho ;

Bezerra, Daniel Pereira ;

Fonseca, Aluisio Marques ;

Pinho Pereira, Marcio Roberto ;

Gomes Lemos, Telma Leda ;

Loiola Pessoa, Otilia Deusdenia ;

Pessoa, Claudia ;

de Moraes, Manoel Odorico ;

Negreiros Nunes Alves, Ana Paula ;

Costa-Lotufo, Leticia Veras .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2007, 30 (08) :1416-1421

[9]

Fonseca A. M., 2003, THESIS U FEDERAL CEA

[10] Constituents of the essential oil of Capraria biflora from northeast Brazil [J].

Fonseca, AM ;

Pessoa, ODL ;

Lemos, TLG ;

Nascimento, RF .

JOURNAL OF ESSENTIAL OIL RESEARCH, 2006, 18 (02) :158-159

← 1 2 3 →