Bone mineral density of patients with thalassemia major: Four-year follow-up

被引:40
作者
Molyvda-Athanasopoulou, E [1 ]
Sioundas, A
Karatzas, N
Aggellaki, M
Pazaitou, K
Vainas, I
机构
[1] Aristotelian Univ Salonika, GR-54006 Salonika, Greece
[2] St Paul Hosp, Thalassemia Unit, Salonika, Greece
关键词
osteoporosis; thalassemia major; bone mineral density; dual energy X-ray absorptiometry;
D O I
10.1007/s002239900637
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The purpose of this study was to evaluate the bone mineral density (BMD) of 50 patients aged 9-28 years, with thalassemia major and to assess the alterations of bone density in a 4-year follow-up study. They were measured with a DPX densitometer at the lumbar spine and femur area and divided into three groups: preadolescents, adolescents, and adults. All patients received calcium and vitamin D supplements, and 8 of the 50 received hormone replacement therapy (HRT). All patients had a significantly lower BMD compared with healthy subjects. Mean values of lumbar BMD of the three groups were 1.3, 2, and 3 standard deviations (SDs) lower than those of healthy subjects of the same age. All adolescent patients with normal gonadal function and those who received HRT showed an increase in BMD during the period of the study. Adult:patients also showed an increase in bone density as long as the treatment lasted. However, adolescent and adult patients who had hypogonadotropic hypogonadism but could not get therapy showed a decrease in bone density. BMD of patients with thalassemia major shows a good index of bone status which should be evaluated, especially for the determination and follow-up of therapy.
引用
收藏
页码:481 / 484
页数:4
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