Vascular protection by high-density lipoprotein-associated sphingosine-1-phosphate

被引：4

作者：

Wang, Xi ^{[1
]}

Wang, Fan ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing 100853, Peoples R China

来源：

JOURNAL OF GERIATRIC CARDIOLOGY | 2017年 / 14卷 / 11期

关键词：

ApoM; HDL-associated S1P; Vascular function; CORONARY-ARTERY-DISEASE; ENDOTHELIAL BARRIER FUNCTION; APOLIPOPROTEIN M; SPHINGOSINE; 1-PHOSPHATE; CYCLOOXYGENASE-2; EXPRESSION; PROSTACYCLIN PRODUCTION; SPROUTING ANGIOGENESIS; TRANSPORTER SPNS2; HDL METABOLISM; CELLS;

D O I：

10.11909/j.issn.1671-5411.2017.11.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epidemiological studies and animal experiments have consistently demonstrated cardiovascular protection by high-density lipoprotein (HDL). Findings from a growing number of studies further indicate that sphingosine-1-phosphate (S1P) mediates many of the beneficial effects of HDL on the cardiovascular system, including vasodilatation, angiogenesis, maintenance of endothelial barrier function, and protection against atherosclerosis and ischemia/reperfusion injury. In this review, we summarize the most recent literature investigating the effects of HDL-S1P on cardiovascular health and highlight potential opportunities for clinical translation of these findings.

引用

页码：696 / 702

页数：7

共 66 条

[1] High density lipoprotein-associated sphingosine 1-phosphate promotes endothelial barrier function [J].

Argraves, Kelley M. ;

Gazzolo, Patrick J. ;

Groh, Eric M. ;

Wilkerson, Brent A. ;

Matsuura, Bryan S. ;

Twal, Waleed O. ;

Hammad, Samar M. ;

Argraves, W. Scott .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (36) :25074-25081

[2] The Apolipoprotein M-Sphingosine-1-Phosphate Axis: Biological Relevance in Lipoprotein Metabolism, Lipid Disorders and Atherosclerosis [J].

Arkensteijn, Bas W. C. ;

Berbee, Jimmy F. P. ;

Rensen, Patrick C. N. ;

Nielsen, Lars B. ;

Christoffersen, Christina .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (03) :4419-4431

[3] The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes [J].

Bekpinar, S. ;

Yenidunya, G. ;

Gurdol, F. ;

Unlucerci, Y. ;

Aycan-Ustyol, E. ;

Dinccag, N. .

CLINICAL BIOCHEMISTRY, 2015, 48 (18) :1264-1267

[4] S1P1 inhibits sprouting angiogenesis during vascular development [J].

Ben Shoham, Adi ;

Malkinson, Guy ;

Krief, Sharon ;

Shwartz, Yulia ;

Ely, Yona ;

Ferrara, Napoleone ;

Yaniv, Karina ;

Zelzer, Elazar .

DEVELOPMENT, 2012, 139 (20) :3859-3869

[5] An update on the biology of sphingosine 1-phosphate receptors [J].

Blaho, Victoria A. ;

Hla, Timothy .

JOURNAL OF LIPID RESEARCH, 2014, 55 (08) :1596-1608

[6] Regulation of Mammalian Physiology, Development, and Disease by the Sphingosine 1-Phosphate and Lysophosphatidic Acid Receptors [J].

Blaho, Victoria A. ;

Hla, Timothy .

CHEMICAL REVIEWS, 2011, 111 (10) :6299-6320

[7] Apolipoprotein M in lipid metabolism and cardiometabolic diseases [J].

Borup, Anna ;

Christensen, Pernille M. ;

Nielsen, Lars B. ;

Christoffersen, Christina .

CURRENT OPINION IN LIPIDOLOGY, 2015, 26 (01) :48-55

[8] Sphingosine kinase 1 in viral infections [J].

Carr, Jillian M. ;

Mahalingam, Suresh ;

Bonder, Claudine S. ;

Pitson, Stuart M. .

REVIEWS IN MEDICAL VIROLOGY, 2013, 23 (02) :73-84

[9] S1P Prophylaxis Mitigates Acute Hypobaric Hypoxia-induced Molecular, Biochemical, and Metabolic Disturbances: A Preclinical Report [J].

Chawla, Sonam ;

Rahar, Babita ;

Saxena, Shweta .

IUBMB LIFE, 2016, 68 (05) :365-375

[10] Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling [J].

Cheng, Jung-Chien ;

Chang, Hsun-Ming ;

Liu, Pang-Pin ;

Leung, Peter C. K. .

CELLULAR SIGNALLING, 2016, 28 (06) :643-651

← 1 2 3 4 5 6 7 →