Role of Dietary Polyphenols in Adipose Tissue Browning: A Narrative Review

被引:8
作者
Salazar, Juan [1 ]
Cano, Climaco [1 ]
Perez, Jose L. [1 ]
Castro, Ana [1 ]
Diaz, Maria P. [1 ]
Garrido, Bermary [1 ]
Carrasquero, Ruben [1 ]
Chacin, Maricarmen [2 ]
Velasco, Manuel [3 ]
Marco, Luis D. [4 ]
Rojas-Quintero, Joselyn [5 ]
Bermudez, Valmore [2 ]
机构
[1] Univ Zulia, Endocrine & Metab Dis Res Ctr, Sch Med, 20th Ave, Maracaibo 4004, Venezuela
[2] Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla, Colombia
[3] Univ Cent Venezuela, Escuela Med Jose Maria Vargas, Caracas, Venezuela
[4] Hosp Clin Univ, Nephrol Dept, INCLIVA, Valencia, Spain
[5] Harvard Med Sch, Brigham & Womens Hosp, Pulm & Crit Care Med Dept, Boston, MA 02115 USA
关键词
Polyphenols; obesity; thermogenesis; adipose tissue browning; energy expenditure; nutraceuticals; ACTIVATED PROTEIN-KINASE; ONION PEEL EXTRACT; FAT-LIKE PHENOTYPE; UNCOUPLING PROTEIN-1; GREEN TEA; MITOCHONDRIAL BIOGENESIS; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; COLD-EXPOSURE; ENERGY-EXPENDITURE;
D O I
10.2174/1381612826666200701211422
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Lifestyle modifications such as energy restriction and increased physical activity are highly effective in the management of obesity. However, adherence to these therapeutic approaches is poor. On the other hand, synthetic drugs used for obesity control are plagued by adverse effects. Despite these failures, adipose tissue is still an attractive therapeutic target for novel molecules, and thus, the characterisation of new and safer anti-obesity drugs is of significant interest. For this reason, in recent years, phenolic constituents of diverse plants have drawn much attention due to their health-promoting properties, opening new research lines related to brown adipose tissue activation and white adipose tissue (WAT) browning. The goal is to increase energy expenditure levels through thermogenic activity activation by multiple factors, like polyphenols. The suggested mechanisms by which polyphenols can modulate thermogenesis include Nor-epinephrine/Catechol-O-Methyl-Transferase (NE/COMT) inhibition, PPAR gamma co-activator alpha (PGC-1 alpha)-dependent pathways activation, and mitochondrial biogenesis, among others. Although polyphenols such as quercetin, catechins, chrysin, luteolin, curcumin, resveratrol, gallic acid, and lignans have shown a positive effect on Non-Shivering Thermogenesis and WAT browning, most of them have only been active in murine models or in vitro systems, and their reproducibility in humans has to be proved. Probably in the future, an approach that includes these compounds as part of the nutritional regimen in conjunction with physical exercise, pharmacological and surgical therapy, would allow modulating a pathophysiological mechanism that is still elusive.
引用
收藏
页码:4444 / 4460
页数:17
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