ELECTROCHEMICAL AND SPECTRAL STUDY OF CYCLODEXTRINS INTERACTIONS WITH SOME PHARMACEUTICAL SUBSTANCES

被引：0
|
作者：
Fritea, Luminita
Tertis, Mihaela
Topala, Tamara Liana
Sandulescu, Robert [1 ]
机构：
[1] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Analyt Dept, Cluj Napoca 400349, Romania
来源：
FARMACIA | 2013年 / 61卷 / 06期
关键词：
beta-cyclodextrin; carbon paste electrode; voltammetry; uric acid; ascorbic acid; BETA-CYCLODEXTRIN; VOLTAMMETRIC DETERMINATION; INCLUSION COMPLEX; SAMPLES; FORMULATIONS; PARACETAMOL; REDUCTION; BEHAVIOR;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The influence of cyclodextrins on the electrochemical response of some pharmaceutical molecules has been investigated on carbon paste electrode (CPE) using cyclic voltammetry (CV) and square wave voltammetry (SWV). The oxidation peak of the analytes is shifted to internal positive potential values and the current intensity is decreased, modifications which can be explained by the formation of inclusion complexes. FUR studies were used to confirm the complexation. Carbon paste electrodes modified with beta-cyclodextrin (CPE/ beta-CD) showed an enhanced electrochemical response of ascorbic and uric acid in comparison with the unmodified carbon paste electrode.
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页码：1054 / 1068
页数：15
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