A case of exogenous corticosteroid-induced Kaposi's sarcoma that developed after a cure of endogenous hypercortisolism

被引：3

作者：

Yoo, Soyeon ^{[1
]}

Moon, Shinhang ^{[1
]}

Chin, Sang-Ouk ^{[1
]}

Lee, Sang-Ah ^{[1
,2
]}

Hyun, Changlim ^{[3
]}

Koh, Gwanpyo ^{[1
,2
]}

机构：

[1] Jeju Natl Univ Hosp, Dept Internal Med, Jeju Si 690767, Jeju Do, South Korea

[2] Jeju Natl Univ, Sch Med, Dept Internal Med, Jeju Si 690767, Jeju Do, South Korea

[3] Jeju Natl Univ, Sch Med, Dept Pathol, Jeju Si 690767, Jeju Do, South Korea

来源：

INTERNATIONAL JOURNAL OF CLINICAL PHARMACY | 2015年 / 37卷 / 06期

关键词：

Corticosteroid; Cushing's syndrome; Glucocorticoid; Kaposi's sarcoma; AIDS;

D O I：

10.1007/s11096-015-0181-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Case Kaposi's sarcoma (KS) is a malignant vascular tumor that occurs commonly in patients with acquired immunodeficiency syndrome. KS associated with Cushing's syndrome (CS) is unusual, especially in endogenous CS. Here, we report a case of KS associated with glucocorticoid-replacement therapy after surgical treatment for adrenal CS. A 70-year-old man presented with symptoms and signs of CS with a left adrenal mass. Adrenal CS was confirmed by biochemical studies. After left adrenalectomy, he took oral prednisolone (15 mg/day) to prevent adrenal insufficiency. Ten weeks later, numerous raised purple plaques on the lower extremities were newly detected. The biopsy findings were compatible with KS, but anti-HIV antibodies were negative. After withdrawal of glucocorticoid therapy, the skin lesions regressed completely. Conclusion In this case, KS developed after the use of exogenous corticosteroid but not during endogenous hypercortisolism. This finding suggests that endogenous and exogenous corticosteroid play different roles in the development of KS.

引用

页码：988 / 991

页数：4

共 10 条

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