Role of mitochondrial variation in maternally inherited diabetes and deafness syndrome

被引：15
作者：
Howes, T. [1 ]
Madden, C. [1 ]
Dasgupta, S. [1 ]
Saeed, S. [2 ]
Das, V. [1 ]
机构：
[1] Manchester Royal Infirm, Univ Dept Audiol Med, Manchester M13 9WL, Lancs, England
[2] Manchester Royal Infirm, Univ Dept Otolaryngol Head & Neck Surg, Manchester M13 9WL, Lancs, England
来源：
JOURNAL OF LARYNGOLOGY AND OTOLOGY | 2008年 / 122卷 / 11期
关键词：
Sensorineural Hearing Loss; Cochlear Implantation; Mitochondrial DNA; MIDD; Heteroplasmy;
D O I：
10.1017/S0022215108001503
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Maternally inherited diabetes and deafness syndrome is caused by the mitochondrial deoxyribonucleic acid mutation 3243 A > G (where A = adenine and G = guanine). The degree of heteroplasmy of the mitochondrial deoxyribonucleic acid may correlate with the rate of progression of the hearing loss. This has important implications for counselling patients with this pathology. Cochlear implantation is a successful method of rehabilitation for patients with hearing loss as part of this syndrome.
引用
收藏
页码：1249 / 1252
页数：4
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