Unconsciousness and sedation as precipitating factors of diabetic ketoacidosis

被引：2

作者：

Palmiere, Cristian ^{[1
]}

Lesta, Maria del Mar ^{[1
]}

Sabatasso, Sara ^{[1
]}

Lobrinus, Johannes Alexander ^{[2
]}

Augsburger, Marc ^{[1
]}

Werner, Dominique ^{[3
]}

机构：

[1] Univ Ctr Legal Med, CH-1011 Lausanne, Switzerland

[2] Univ Hosp Geneva, Div Clin Pathol, CH-1211 Geneva, Switzerland

[3] Univ Lausanne Hosp, Clin Chem Lab, CH-1011 Lausanne, Switzerland

来源：

JOURNAL OF FORENSIC AND LEGAL MEDICINE | 2013年 / 20卷 / 07期

关键词：

Unconsciousness; Postmortem biochemistry; Diabetes; Ketoacidosis; Vitreous humor; Ketone bodies; BLOOD; MELLITUS; LEVEL; DEATH; DRUG;

D O I：

10.1016/j.jflm.2013.06.030

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

The aim of this study was to identify medico-legal situations characterized by increased vitreous glucose concentrations, potentially lethal blood 3-hydroxybutyrate levels and conditions that could either incapacitate or lead to death on their own. The above was investigated in order to verify whether prolonged states of unconsciousness may play a role in precipitating diabetic ketoacidosis. Six groups of medico-legal situations (corresponding to 206 autopsy cases) were identified. Among these, three cases were characterized by pathologically increased vitreous glucose and blood 3-hydroxybutyrate levels. In one case diabetic ketoacidosis coexisted with underlying features that might have potentially incapacitated or lead to death on their own, whereas in two cases it corresponded with potentially lethal or lethal drug concentrations. The results of this study highlight the usefulness of systematically performing biochemistry in order to identify diabetic ketoacidosis-related deaths, even when autopsy and toxicology results provide apparently conclusive findings. (C) 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

引用

页码：830 / 835

页数：6

共 29 条

[1] Diabetic Ketoacidosis A Silent Death [J].