MicroRNA-induced drug resistance in gastric cancer

被引：53
作者：
Dehghanzadeh, Rashedeh [1 ,2 ]
Jadidi-Niaragh, Farhad [3 ]
Gharibi, Tohid [1 ,2 ]
Yousefi, Mehdi [1 ,2 ]
机构：
[1] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Sch Med, Dept Immunol, Tabriz, Iran
[3] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2015年 / 74卷
关键词：
microRNA; Drug resistance; Gastric cancer; REGULATES MULTIDRUG-RESISTANCE; TUMOR-SUPPRESSOR NETWORK; GROWTH-FACTOR RECEPTOR; BREAST-CANCER; DOWN-REGULATION; TARGETING BCL2; CELL-LINES; POTENTIAL THERAPEUTICS; COLORECTAL-CANCER; SIRNA DELIVERY;
D O I：
10.1016/j.biopha.2015.08.009
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Drug resistance remains one of the major reasons of therapy failure in gastric cancer patients. Although the mechanisms of anticancer drug resistance have been broadly investigated, they have not been completely understood. Accumulating reports have recently highlighted the involvement of endogenous non-coding RNAs, known as microRNAs, in the evolution of cancer cell drug resistance. MiRNAs have been characterized as major regulators of crucial genes implicated in the chemoresistance phenotype of gastric cancer cells. MiRNA-based therapy in the future may provide a new strategy to overcome drug resistance. This review summarizes the current knowledge on the role of miRNAs in regulating drug resistance in gastric cancer and their potential to develop targeted therapies and personalized treatment for managing drug resistant gastric cancers. (C) 2015 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：191 / 199
页数：9
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