Organocatalytic formal [2+2] cycloaddition initiated by vinylogous Friedel-Crafts alkylation: enantioselective synthesis of substituted cyclobutane derivatives

被引：51

作者：

Duan, Guo-Jian ^{[1
]}

Ling, Jun-Bing ^{[1
]}

Wang, Wei-Ping ^{[1
]}

Luo, Yong-Chun ^{[1
]}

Xu, Peng-Fei ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 41期

关键词：

DIELS-ALDER REACTIONS; BONDING CATALYSIS; ALDOL REACTION; ALDEHYDES; INDOLE; SCEPTRIN; AGENT;

D O I：

10.1039/c3cc41785a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An organocatalytic vinylogous Friedel-Crafts alkylation-initiated formal [2+2] cycloaddition was successfully developed based on tandem iminium-enamine activation of enals. Transformable pyrrole-functionalized cyclobutanes with three contiguous stereo-centers were readily obtained with excellent levels of regio-, diastereo- and enantiocontrol.

引用

页码：4625 / 4627

页数：3

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