Compressed wormlike chain moving out of confined space: A model of DNA ejection from bacteriophage

被引：11
作者：
Wang, Ji-Zeng [1 ]
Li, Long [1 ]
Gao, Hua-Jian [2 ]
机构：
[1] Lanzhou Univ, Key Lab Mech Disaster & Environm Western China, Minist Educ, Sch Civil Engn & Mech, Lanzhou 730000, Gansu, Peoples R China
[2] Brown Univ, Sch Engn, Providence, RI 02912 USA
来源：
ACTA MECHANICA SINICA | 2012年 / 28卷 / 04期
基金：
美国国家科学基金会; 中国国家自然科学基金;
关键词：
DNA ejection; Bacteriophage; Wormlike chain model; Confined semi-flexible polymer; Drag coefficient; DYNAMICS; LAMBDA; FORCES; DILUTE;
D O I：
10.1007/s10409-012-0121-8
中图分类号：
TH [机械、仪表工业];
学科分类号：
0802 ;
摘要：
The molecular biomechanics of DNA ejection from bacteriophage is of interest to not only fundamental biological understandings but also practical applications such as the design of advanced site-specific and controllable drug delivery systems. In this paper, we analyze the viscous motion of a semiflexible polymer chain coming out of a strongly confined space as a model to investigate the effects of various structure confinements and frictional resistances encountered during the DNA ejection process. The theoretically predicted relations between the ejection speed, ejection time, ejection length, and other physical parameters, such as the phage type, total genome length and ionic state of external buffer solutions, show excellent agreement with in vitro experimental observations in the literature.
引用
收藏
页码：1219 / 1226
页数：8
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