The Frequency of Invariant Natural Killer T Cells Correlates with the Severity of Myocarditis

被引：10

作者：

Wang, Xinggang ^{[1
]}

Li, Minghui ^{[1
]}

Xie, Yeqing ^{[1
]}

Yu, Ying ^{[1
]}

Liu, Guijian ^{[1
]}

Yu, Yong ^{[1
]}

Yang, Xiangdong ^{[1
]}

Zou, Yunzeng ^{[1
]}

Ge, Junbo ^{[1
]}

Chen, Ruizhen ^{[1
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Key Lab Viral Heart Dis,Minist Publ Hlth, Shanghai 200032, Peoples R China

来源：

VIRAL IMMUNOLOGY | 2014年 / 27卷 / 03期

基金：

中国国家自然科学基金;

关键词：

COXSACKIEVIRUS B3 INFECTION; VIRAL MYOCARDITIS; TH17; CELLS; NKT CELLS; ACTIVATION; MOUSE; PROTECTS;

D O I：

10.1089/vim.2013.0078

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Invariant natural killer T cells (iNKT) perform different functions in different diseases. The cells were reported to protect myocarditis. However, the detail relationships between iNKT and Coxsackievirus B3 (CVB3)-induced myocarditis remain unclear. In order to investigate the correlation between the severity of CVB3-induced inflammation infiltration and the proportion of iNKT in the spleen and circulating blood, BALB/c mice were grouped into three groups according to the inflammation infiltration area of heart sections. The proportion of iNKT in CD3-positive cells in the spleen correlated negatively with the inflammation area (linear fit; R-2=0.93) and virus capsid protein VP1 (linear fit; R-2=0.84) in the myocardial tissue, while the proportion of iNKT in CD3-positive cells in the PBMC positively correlated with the inflammation area (linear fit; R-2=0.91) and virus capsid protein VP1 (linear fit; R-2=0.93) in the myocardial tissue. The results imply that iNKT might be used as a parameter for the diagnosis of myocarditis in clinical practice.

引用

页码：88 / 95

页数：8

共 24 条

[1]

Chuang Y-P, 2012, CLIN DEV IMMUNOL, V2012, P8

[2] Medical Progress: Myocarditis. [J].

Cooper, Leslie T., Jr. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (15) :1526-1538

[3] Republished: Pathogenesis and diagnosis of myocarditis [J].

Elamm, Chantal ;

Fairweather, DeLisa ;

Cooper, Leslie T. .

POSTGRADUATE MEDICAL JOURNAL, 2012, 88 (1043) :539-544

[4] Fulminant myocarditis [J].

Gupta, Sachin ;

Markham, David W. ;

Drazner, Mark H. ;

Mammen, Pradeep P. A. .

NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, 2008, 5 (11) :693-706

[5] Role of CD1d in Coxsackievirus B3-induced myocarditis [J].

Huber, S ;

Sartini, D ;

Exley, M .

JOURNAL OF IMMUNOLOGY, 2003, 170 (06) :3147-3153

[6] Slam Haplotype 2 Promotes NKT But Suppresses Vγ4+ T-Cell Activation in Coxsackievirus B3 Infection Leading to Increased Liver Damage But Reduced Myocarditis [J].

Huber, Sally Ann ;

Roberts, Brian ;

Moussawi, Mohamad ;

Boyson, Jonathan E. .

AMERICAN JOURNAL OF PATHOLOGY, 2013, 182 (02) :401-409

[7] Natural killer T cells promote collagen-induced arthritis in DBA/1 mice [J].

Jung, Sundo ;

Shin, Hyun-suk ;

Hong, Changwan ;

Lee, Hyunji ;

Park, Yoon-Kyung ;

Shin, Jung Hoon ;

Hong, Seokmann ;

Lee, Gap Ryol ;

Park, Se-Ho .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 390 (03) :399-403

[8] Update on Myocarditis [J].

Kindermann, Ingrid ;

Barth, Christine ;

Mahfoud, Felix ;

Ukena, Christian ;

Lenski, Matthias ;

Yilmaz, Ali ;

Klingel, Karin ;

Kandolf, Reinhard ;

Sechtem, Udo ;

Cooper, Leslie T. ;

Boehm, Michael .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (09) :779-792

[9] Initial weight and virus dose: two factors affecting the onset of acute coxsackievirus B3 myocarditis in C57BL/6 mouse-a histopathology-based study [J].

Li, Minghui ;

Wang, Xinggang ;

Xie, Yuquan ;

Xie, Yeqing ;

Zhang, Xian ;

Zou, Yunzeng ;

Ge, Junbo ;

Chen, Ruizhen .

CARDIOVASCULAR PATHOLOGY, 2013, 22 (01) :96-101

[10] Enteroviral capsid protein VP1 is present in myocardial tissues from some patients with myocarditis or dilated cardiomyopathy [J].

Li, YW ;

Bourlet, T ;

Andreoletti, L ;

Mosnier, JF ;

Peng, TQ ;

Yang, YZ ;

Archard, LC ;

Pozzetto, B ;

Zhang, HY .

CIRCULATION, 2000, 101 (03) :231-234

← 1 2 3 →