Chromatographic separation of naproxen enantiomers using hydroxypropyl-β-cyclodextrin as chiral mobile phase additive

被引：20

作者：

Jiao, FP

Huang, KL ^{[1
]}

Ning, FR

Hu, WG

Yu, JG

机构：

[1] Cent S Univ, Sch Chem & Chem Engn, Changsha 410083, Peoples R China

[2] Xiangtan Univ, Sch Chem Engn, Xiangtan, Peoples R China

来源：

SEPARATION SCIENCE AND TECHNOLOGY | 2006年 / 41卷 / 09期

基金：

中国国家自然科学基金;

关键词：

chromatographic separation; naproxen enantiomers; hydroxypropyl-beta-cyclodextrin;

D O I：

10.1080/01496390600674885

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chromatographic separation of naproxen has been studied using hydroxypropyl-beta-cyclodextrin as chiral mobile phase additive. The effects of mobile-phase composition were researched in detail. The appropriate composition of mobile phase was 85:15 (v/v) aqueous with 0.5% TEA at pH 3.5/ ethanol containing 25 mM HP-beta-CD, and the column temperature was set of 25 degrees C. Graphs of 1/ k versus [HP-beta-CD] gave good linear relationships, indicating the stoichiometry ratio of naproxen with HP-beta-CD of 1:1. Apparent thermodynamic parameters were also calculated from the plots of ln alpha versus 1/T, it was found that the enantioseparation was enthalpy driven and the inclusion process was exothermic.

引用

页码：1893 / 1906

页数：14

共 18 条

[11] Enantiomeric separation of R,S-naproxen by conventional and nano-liquid chromatography with methyl-β-cyclodextrin as a mobile phase additive [J].