miR-625 down-regulation promotes proliferation and invasion in esophageal cancer by targeting Sox2

被引：60
|
作者：
Wang, Zhiqiang [1 ]
Qiao, Qiao [2 ]
Chen, Min [3 ]
Li, Xianhua [1 ]
Wang, Zhenjun [1 ]
Liu, Chuanxin [1 ]
Xie, Zongtao [1 ]
机构：
[1] Jiangnan Univ, Peoples Hosp Wuxi City 4, Affiliated Hosp, Dept Thorac & Cardiovasc Surg, Wuxi 214062, Peoples R China
[2] Jiangnan Univ, Peoples Hosp Wuxi City 4, Affiliated Hosp, Dept Gastroenterol, Wuxi 214062, Peoples R China
[3] Jiangnan Univ, Peoples Hosp Wuxi City 4, Affiliated Hosp, Dept Clin Lab, Wuxi 214062, Peoples R China
来源：
FEBS LETTERS | 2014年 / 588卷 / 06期
关键词：
miR-625; Sox2; Proliferation; Invasion; Esophageal cancer; EPITHELIAL-MESENCHYMAL TRANSITION; COLORECTAL-CANCER; POOR-PROGNOSIS; TUMOR-METASTASIS; LUNG-CANCER; STEM-CELLS; EXPRESSION; SUPPRESSES; RECEPTOR; GROWTH;
D O I：
10.1016/j.febslet.2014.01.035
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
miR-625 has been reported to exhibit abnormal expression in esophageal cancer (EC), but the mechanism and functions of miR-625 in esophageal cancer remain unclear. miR-625 down-regulation and Sox2 up-regulation were validated by qRT-PCR in 158 EC samples. Low expression of miR-625 promotes cell proliferation and invasion, while high expression of miR-625 has the opposite effect. Sox2, a target gene of miR-625, was examined by luciferase assay and western blot. Our data suggest that miR-625 may regulate the biological processes of EC via controlling Sox2 expression. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：915 / 921
页数：7
相关论文
共 50 条
  • [1] Down-Regulation of miR-140 Induces EMT and Promotes Invasion by Targeting Slug in Esophageal Cancer
    Li, Weiling
    Jiang, Guojun
    Zhou, Jianping
    Wang, Hongmin
    Gong, Zegang
    Zhang, Zheng
    Min, Ke
    Zhu, Hongdi
    Tan, Yongfei
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2014, 34 (05) : 1466 - 1476
  • [2] Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK
    Wang, Ming
    Li, Chenglong
    Nie, Hui
    Lv, Xin
    Qu, Ying
    Yu, Beiqin
    Su, Liping
    Li, Jianfang
    Chen, Xuehua
    Ju, Jingfang
    Yu, Yingyan
    Yan, Min
    Gu, Qinlong
    Zhu, Zhenggang
    Liu, Bingya
    FEBS LETTERS, 2012, 586 (16) : 2382 - 2388
  • [3] Down-regulation of miR-203 induced by Helicobacter pylori infection promotes the proliferation and invasion of gastric cancer by targeting CASK
    Zhou, Xiaoying
    Xu, Guifang
    Yin, Chengqiang
    Jin, Wujuan
    Zhang, Guoxin
    ONCOTARGET, 2014, 5 (22) : 11631 - 11640
  • [4] Down-regulation of MiR-206 Promotes Proliferation and Invasion of Laryngeal Cancer by Regulating VEGF Expression
    Zhang, Tianhong
    Liu, Ming
    Wang, Chunrui
    Lin, Chao
    Sun, Yanan
    Jin, Dejun
    ANTICANCER RESEARCH, 2011, 31 (11) : 3859 - 3863
  • [5] Down-Regulation of miR-183 Promotes Migration and Invasion of Osteosarcoma by Targeting Ezrin
    Zhu, Junfeng
    Feng, Yupeng
    Ke, Zunfu
    Yang, Zheng
    Zhou, Junyi
    Huang, Xiaorong
    Wang, Liantang
    AMERICAN JOURNAL OF PATHOLOGY, 2012, 180 (06): : 2440 - 2451
  • [6] LncRNA RHPN1-AS1 Targeting miR-625/REG3A Promotes Cell Proliferation And Invasion Of Glioma Cells
    Cui, Peng
    Su, Jichun
    Li, Qingmin
    Xu, Guangming
    Zhu, Ningxi
    ONCOTARGETS AND THERAPY, 2019, 12 : 7911 - 7921
  • [7] miR-625 suppresses cell proliferation and migration by targeting HMGA1 in breast cancer
    Zhou, Wen-bin
    Zhong, Cai-neng
    Luo, Xun-peng
    Zhang, Ya-yuan
    Zhang, Gui-ying
    Zhou, Dong-xian
    Liu, Li-ping
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 470 (04) : 838 - 844
  • [8] Downregulation of miR-638 promotes invasion and proliferation by regulating SOX2 and induces EMT in NSCLC
    Xia, Yang
    Wu, Yanhu
    Liu, Bin
    Wang, Pengli
    Chen, Yijiang
    FEBS LETTERS, 2014, 588 (14) : 2238 - 2245
  • [9] Down-regulation of miR-605 promotes the proliferation and invasion of prostate cancer cells by up-regulating EN2
    Zhou, Yao-jun
    Yang, Hong-qiong
    Xia, Wei
    Cui, Li
    Xu, Ren-fang
    Lu, Hao
    Xue, Zhong
    Zhang, Bo
    Tian, Zi-nong
    Cao, Yun-jie
    Xing, Zhao-yu
    Yin, Shuai
    He, Xiao-zhou
    LIFE SCIENCES, 2017, 190 : 7 - 14
  • [10] Down-regulation of miR-144 promotes thyroid cancer cell invasion by targeting ZEB1 and ZEB2
    Guan, Hongyu
    Liang, Weiwei
    Xie, Zhiwei
    Li, Hai
    Liu, Juan
    Liu, Liehua
    Xiu, Lingling
    Li, Yanbing
    ENDOCRINE, 2015, 48 (02) : 566 - 574
12345