Limitations of high performance liquid chromatography with inductively coupled plasma mass spectrometric detection for speciation analysis of trace metals in biological samples

被引：0

作者：

Szpunar, J ^{[1
]}

Chassaigne, H ^{[1
]}

Makarov, A ^{[1
]}

Lobinski, R ^{[1
]}

机构：

[1] CNRS, F-64000 Pau, France

来源：

CHEMIA ANALITYCZNA | 1999年 / 44卷 / 03期

关键词：

speciation; HPLC-ICP MS; electrospray tandem MS; polysaccharides; cobalamin; metallothionein; enzymic hydrolysis;

D O I：

暂无

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Two current limitations of speciation analysis by HPLC-ICP MS: the difficulty to recover quantitatively intact metal species from solid samples and the difficulties with the identification of chromatographic signals are discussed. The illustrative experimental examples include investigation of solid-liquid extraction of metal-polysaccharide complexes from a food sample with customized mixtures of enzymes, detection, identification and investigation of the composition and stoichiometry of Cd, Zn-metallothionein complexes by HPLC-ICP MS and HPLC-electrospray (ESI) M'S without and with post-column derivatization, and structural characterization and quantification of cobalt complexes with macrocyclic ligands by ESI MS and tandem ESI MS.

引用

页码：351 / 362

页数：12

共 24 条

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