Saffron and its derivatives, crocin, crocetin and safranal: a patent review

被引：80
作者：
Rameshrad, Maryam [1 ]
Razavi, Bibi Marjan [2 ]
Hosseinzadeh, Hossein [3 ]
机构：
[1] Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, Dept Pharmacodynam & Toxicol, Mashhad, Iran
[2] Mashhad Univ Med Sci, Targeted Drug Delivery Res Ctr, Dept Pharmacodynam & Toxicol, Sch Pharm, Mashhad, Iran
[3] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Pharmaceut Res Ctr, Mashhad, Iran
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2018年 / 28卷 / 02期
关键词：
Crocetin; crocin; Crocus sativus; patent; saffron; safranal; CHRONIC CONSTRICTION INJURY; INDUCED OXIDATIVE DAMAGE; SYSTOLIC BLOOD-PRESSURE; SATIVUS AQUEOUS EXTRACT; ACTIVE CONSTITUENT; SUBCHRONIC EXPOSURE; SAFETY EVALUATION; NANO-EMULSIONS; ARABIC GUM; L;
D O I：
10.1080/13543776.2017.1355909
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Introduction: Saffron and its main components have traditionally been used as pharmaceutical agents. Current experimental research projects have also exhibited their applications in a wide spectrum of disorder treatments. Area covered: This review covers the demonstrated findings and patents on therapeutic/pharmaceutical properties of saffron and related derivatives, since 2000 to bold their outstanding merit on human health. An extensive literature review was performed in USP Patent, Patentscope, Espacenet and Google Patent in the field of CNS, cardiovascular, urogenital, dermatological and inflammatory disorders. Expert opinion: The growing body of patents showed the value of saffron and the respective crucial components alone or in combination with the other raw materials, herbal extracts, to apply in various therapeutic/pharmaceutical areas. They could be engaged as an adjuvant treatment in phototherapy, cancer, cardiovascular and neurodegenerative diseases and hypoxia-induced dangerous conditions. However, the application of these components in the clinic has been limited to very few drugs yet. This might be due poor clinical trials data. According the human trend toward the use of plant-derived compounds instead of medicines derived from chemical substances, special attention must be focused to link the worth of saffron, herbal medicine of third millennium, from basic sciences to patients' bed.
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页码：147 / 165
页数：19
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