Biological activity of synthetic ionophores: ion transporters as prospective drugs?

被引：92
作者：
Alfonso, Ignacio [1 ]
Quesada, Roberto [2 ]
机构：
[1] Inst Quim Avanzada Cataluna IQAC CSIC, Dept Quim Biol & Modelizac Mol, E-08034 Barcelona, Spain
[2] Univ Burgos, Fac Ciencias, Dept Quim, Burgos 09001, Spain
来源：
CHEMICAL SCIENCE | 2013年 / 4卷 / 08期
关键词：
TRANSMEMBRANE ANION TRANSPORTERS; HYDRAPHILE CHANNELS; CHLORIDE TRANSPORT; BILAYER-MEMBRANES; CELL-DEATH; IN-VITRO; PEPTIDE NANOSTRUCTURES; BACTERIAL PRODIGININES; ANTICANCER ACTIVITY; EPITHELIAL-CELLS;
D O I：
10.1039/c3sc50882j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The control of ion transport and homeostasis is a critical function of living organisms. In this perspective, an overview of different synthetic systems capable of facilitating the transmembrane transport of ions along with the biological activity exerted by these compounds is presented. Examples of both cation selective and anion selective transporters are highlighted. The potential future applications of these systems in the treatment of conditions derived from the dysregulation of natural ion transport mechanisms and the development of new antimicrobials and anticancer drugs are discussed.
引用
收藏
页码：3009 / 3019
页数：11
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