Mutations in the DNMT3A exon 23 independently predict poor outcome in older patients with acute myeloid leukemia: a SWOG report

被引:44
作者
Ostronoff, F. [1 ,2 ]
Othus, M. [3 ]
Ho, P. A. [1 ,4 ]
Kutny, M. [5 ]
Geraghty, D. E. [1 ]
Petersdorf, S. H. [2 ]
Godwin, J. E. [6 ]
Willman, C. L. [7 ]
Radich, J. P. [1 ,2 ]
Appelbaum, F. R. [1 ,2 ]
Stirewalt, D. L. [1 ,2 ]
Meshinchi, S. [1 ,4 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
[2] Univ Washington, Sch Med, Seattle Canc Care Alliance, Div Med Oncol, Seattle, WA USA
[3] Fred Hutchinson Canc Res Ctr, SWOG Grp Stat Ctr, Seattle, WA 98104 USA
[4] Univ Washington, Sch Med, Div Pediat Hematol Oncol, Seattle, WA USA
[5] Univ Alabama Birmingham, Div Pediat Hematol Oncol, Birmingham, AL USA
[6] So Illinois Univ, Inst Canc, Springfield, IL USA
[7] Univ New Mexico, Canc Res & Treatment Ctr, UNM Canc Res Facil, Albuquerque, NM 87131 USA
关键词
ACUTE MYELOGENOUS LEUKEMIA; PROGNOSTIC IMPACT; ONCOLOGY-GROUP; AML;
D O I
10.1038/leu.2012.168
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:238 / 241
页数:5
相关论文
共 18 条
[1]   Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin: a Southwest Oncology Group study [J].
Anderson, JE ;
Kopecky, KJ ;
Willman, CL ;
Head, D ;
O'Donnell, MR ;
Luthardt, FW ;
Norwood, TH ;
Chen, IM ;
Balcerzak, SP ;
Johnson, DB ;
Appelbaum, FR .
BLOOD, 2002, 100 (12) :3869-3876
[2]   Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. [J].
Falini, B ;
Mecucci, C ;
Tiacci, E ;
Alcalay, M ;
Rosati, R ;
Pasqualucci, L ;
La Starza, R ;
Diverio, D ;
Colombo, E ;
Santucci, A ;
Bigerna, B ;
Pacini, R ;
Pucciarini, A ;
Liso, A ;
Vignetti, M ;
Fazi, P ;
Meani, N ;
Pettirossi, V ;
Saglio, G ;
Mandelli, F ;
Lo-Coco, F ;
Pelicci, P ;
Martelli, MF .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (03) :254-266
[3]   A double-blind placebo-controlled trial of granulocyte colony-stimulating factor in elderly patients with previously untreated acute myeloid leukemia: A Southwest Oncology Group study (9031) [J].
Godwin, JE ;
Kopecky, KJ ;
Head, DR ;
Willman, CL ;
Leith, CP ;
Hynes, HE ;
Balcerzak, SP ;
Appelbaum, FR .
BLOOD, 1998, 91 (10) :3607-3615
[4]   Leukemic Mutations in the Methylation-Associated Genes DNMT3A and IDH2 Are Rare Events in Pediatric AML: A Report From the Children's Oncology Group [J].
Ho, Phoenix A. ;
Kutny, Matthew A. ;
Alonzo, Todd A. ;
Gerbing, Robert B. ;
Joaquin, Jason ;
Raimondi, Susana C. ;
Gamis, Alan S. ;
Meshinchi, Soheil .
PEDIATRIC BLOOD & CANCER, 2011, 57 (02) :204-209
[5]   Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group [J].
Ho, Phoenix A. ;
Alonzo, Todd A. ;
Gerbing, Robert B. ;
Pollard, Jessica ;
Stirewalt, Derek L. ;
Hurwitz, Craig ;
Heerema, Nyla A. ;
Hirsch, Betsy ;
Raimondi, Susana C. ;
Lange, Beverly ;
Franklin, Janet L. ;
Radich, Jerald P. ;
Meshinchi, Soheil .
BLOOD, 2009, 113 (26) :6558-6566
[6]   DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications [J].
Hou, Hsin-An ;
Kuo, Yuan-Yeh ;
Liu, Chieh-Yu ;
Chou, Wen-Chien ;
Lee, Ming Cheng ;
Chen, Chien-Yuan ;
Lin, Liang-In ;
Tseng, Mei-Hsuan ;
Huang, Chi-Fei ;
Chiang, Ying-Chieh ;
Lee, Fen-Yu ;
Liu, Ming-Chih ;
Liu, Chia-Wen ;
Tang, Jih-Luh ;
Yao, Ming ;
Huang, Shang-Yi ;
Ko, Bor-Sheng ;
Hsu, Szu-Chun ;
Wu, Shang-Ju ;
Tsay, Woei ;
Chen, Yao-Chang ;
Tien, Hwei-Fang .
BLOOD, 2012, 119 (02) :559-568
[7]   DNMT3A Mutations in Acute Myeloid Leukemia. [J].
Ley, Timothy J. ;
Ding, Li ;
Walter, Matthew J. ;
McLellan, Michael D. ;
Lamprecht, Tamara ;
Larson, David E. ;
Kandoth, Cyriac ;
Payton, Jacqueline E. ;
Baty, Jack ;
Welch, John ;
Harris, Christopher C. ;
Lichti, Cheryl F. ;
Townsend, R. Reid ;
Fulton, Robert S. ;
Dooling, David J. ;
Koboldt, Daniel C. ;
Schmidt, Heather ;
Zhang, Qunyuan ;
Osborne, John R. ;
Lin, Ling ;
O'Laughlin, Michelle ;
McMichael, Joshua F. ;
Delehaunty, Kim D. ;
McGrath, Sean D. ;
Fulton, Lucinda A. ;
Magrini, Vincent J. ;
Vickery, Tammi L. ;
Hundal, Jasreet ;
Cook, Lisa L. ;
Conyers, Joshua J. ;
Swift, Gary W. ;
Reed, Jerry P. ;
Alldredge, Patricia A. ;
Wylie, Todd ;
Walker, Jason ;
Kalicki, Joelle ;
Watson, Mark A. ;
Heath, Sharon ;
Shannon, William D. ;
Varghese, Nobish ;
Nagarajan, Rakesh ;
Westervelt, Peter ;
Tomasson, Michael H. ;
Link, Daniel C. ;
Graubert, Timothy A. ;
DiPersio, John F. ;
Mardis, Elaine R. ;
Wilson, Richard K. .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (25) :2424-2433
[8]   Recurrent DNMT3A R882 Mutations in Chinese Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome [J].
Lin, Jiang ;
Yao, Dong-ming ;
Qian, Jun ;
Chen, Qin ;
Qian, Wei ;
Li, Yun ;
Yang, Jing ;
Wang, Cui-zhu ;
Chai, Hai-yan ;
Qian, Zhen ;
Xiao, Gao-fei ;
Xu, Wen-rong .
PLOS ONE, 2011, 6 (10)
[9]   Age-Related Prognostic Impact of Different Types of DNMT3A Mutations in Adults With Primary Cytogenetically Normal Acute Myeloid Leukemia [J].
Marcucci, Guido ;
Metzeler, Klaus H. ;
Schwind, Sebastian ;
Becker, Heiko ;
Maharry, Kati ;
Mrozek, Krzysztof ;
Radmacher, Michael D. ;
Kohlschmidt, Jessica ;
Nicolet, Deedra ;
Whitman, Susan P. ;
Wu, Yue-Zhong ;
Powell, Bayard L. ;
Carter, Thomas H. ;
Kolitz, Jonathan E. ;
Wetzler, Meir ;
Carroll, Andrew J. ;
Baer, Maria R. ;
Moore, Joseph O. ;
Caligiuri, Michael A. ;
Larson, Richard A. ;
Bloomfield, Clara D. .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (07) :742-750
[10]   Prognostic impact of DNMT3A mutations in patients with intermediate cytogenetic risk profile acute myeloid leukemia [J].
Markova, Jana ;
Michkova, Petra ;
Burckova, Katerina ;
Brezinova, Jana ;
Michalova, Kyra ;
Dohnalova, Alena ;
Maaloufova, Jacqueline Soukupova ;
Soukup, Petr ;
Vitek, Antonin ;
Cetkovsky, Petr ;
Schwarz, Jiri .
EUROPEAN JOURNAL OF HAEMATOLOGY, 2012, 88 (02) :128-135