Regioselective inverse Diels-Alder reaction of unsymmetrical tetrazines with aldehydes and ketones

被引：0
作者：
Adogla, Enoch A. [1 ]
Xu, Yanmei [1 ]
Li, Honglin [1 ]
Wang, Guiren [2 ,3 ]
Wang, Qian
机构：
[1] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA
[2] Univ S Carolina, Dept Mech Engn, Columbia, SC 29208 USA
[3] Univ S Carolina, Biomed Engn Program, Columbia, SC 29208 USA
来源：
ARKIVOC | 2015年
关键词：
Tetrazine; Diels-Alder reaction; regioselectivity; enamine; pyridazine; LIVING CELLS; 1,2,4,5-TETRAZINE; CYCLOADDITIONS; BIOCONJUGATION; PROBES;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The amine-catalyzed inverse electron demand Diels-Alder reaction of unsymmetrical tetrazines with aldehydes and ketones was investigated. We found that only one regioisomer could be observed when pyrrolidine was applied as the catalyst. Using this reaction, fluorogenic dyes could be developed with a tetrazine unit as the "triggering group".
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页数：11
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