Systemic lupus erythematosus with cytophagic histiocytic panniculitis successfully treated with high-dose glucocorticoids and cyclosporine A

被引：7

作者：

Hasegawa, H. ^{[1
,2
]}

Mizoguchi, F. ^{[1
]}

Kohsaka, H. ^{[1
]}

Miyasaka, N. ^{[1
,2
]}

机构：

[1] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Med & Rheumatol, Tokyo 1138519, Japan

[2] Tokyo Med & Dent Univ, Global Ctr Excellence GCOE Program, Int Res Ctr Mol Sci Tooth & Bone Dis, Grad Sch, Tokyo 1138519, Japan

来源：

LUPUS | 2013年 / 22卷 / 03期

关键词：

systemic lupus erythematosus (SLE); cytophagic histiocytic panniculitis (CHP); panniculitis; macrophage activation syndrome (MAS); cyclosporine A; EPSTEIN-BARR-VIRUS; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS;

D O I：

10.1177/0961203313476355

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 37-year-old male with systemic lupus erythematosus (SLE) presented with high fever, subcutaneous indurations, anemia, thrombocytopenia, elevated liver enzymes and hyperferritinemia. Skin biopsy revealed hemophagocytic histiocytes in the adipose tissues. The patient was diagnosed with SLE with cytophagic histiocytic panniculitis (CHP). Treatment with high-dose glucocorticoids and cyclosporine A induced remission of SLE and CHP. CHP is generally a systemic disorder affecting subcutaneous adipose tissues with a high mortality rate. However, based on the present and previously reported cases, we believe that intensive immunosuppression can ameliorate CHP that occurs as a skin manifestation of SLE. Lupus (2013) 22, 316-319.

引用

页码：316 / 319

页数：4

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