HDAC6 and Ovarian Cancer

被引：27

作者：

Haakenson, Joshua ^{[1
]}

Zhang, Xiaohong ^{[1
,2
]}

机构：

[1] Univ S Florida, Morsani Coll Med, Dept Pathol & Cell Biol, Tampa, FL 33612 USA

[2] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Program Mol Oncol, Tampa, FL 33612 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 05期

关键词：

HDAC6; ovarian cancer; cancer-related signaling pathways; inhibitors; cell stress response; motility; oncogenesis; histone deacetylase; HISTONE DEACETYLASE 6; REGULATES AGGRESOME FORMATION; 2 CATALYTIC DOMAINS; CELL-MIGRATION; MICROTUBULE ACETYLATION; GLUCOCORTICOID-RECEPTOR; STRESS GRANULES; PROTEIN; TUBULIN; INHIBITORS;

D O I：

10.3390/ijms14059514

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The special class IIb histone deacetylase, HDAC6, plays a prominent role in many cellular processes related to cancer, including oncogenesis, the cell stress response, motility, and myriad signaling pathways. Many of the lessons learned from other cancers can be applied to ovarian cancer as well. HDAC6 interacts with diverse proteins such as HSP90, cortactin, tubulin, dynein, p300, Bax, and GRK2 in both the nucleus and cytoplasm to carry out these cancerous functions. Not all pro-cancer interactions of HDAC6 involve deacetylation. The idea of using HDAC6 as a target for cancer treatment continues to expand in recent years, and more potent and specific HDAC6 inhibitors are required to effectively down-regulate the tumor-prone cell signaling pathways responsible for ovarian cancer.

引用

页码：9514 / 9535

页数：22

共 151 条

[1] HDAC6 Regulates Androgen Receptor Hypersensitivity and Nuclear Localization via Modulating Hsp90 Acetylation in Castration-Resistant Prostate Cancer [J].

Ai, Junkui ;

Wang, Yujuan ;

Dar, Javid A. ;

Liu, June ;

Liu, Lingqi ;

Nelson, Joel B. ;

Wang, Zhou .

MOLECULAR ENDOCRINOLOGY, 2009, 23 (12) :1963-1972

[2] The Role of HDAC6 in Cancer [J].

Aldana-Masangkay, Grace I. ;

Sakamoto, Kathleen M. .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2011,

[3]

American Cancer Society, 2013, CANC FACTS FIG

[4] Suberoylanilide hydroxamic acid partly reverses resistance to paclitaxel in human ovarian cancer cell lines [J].

Angelucci, Adriano ;

Mari, Marianna ;

Millimaggi, Danilo ;

Giusti, Ilaria ;

Carta, Gaspare ;

Bologna, Mauro ;

Dolo, Vincenza .

GYNECOLOGIC ONCOLOGY, 2010, 119 (03) :557-563

[5]

[Anonymous], 2007, BIOL CANC

[6] R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies [J].

Arts, J. ;

Angibaud, P. ;

Marieen, A. ;

Floren, W. ;

Janssens, B. ;

King, P. ;

van Dun, J. ;

Janssen, L. ;

Geerts, T. ;

Tuman, R. W. ;

Johnson, D. L. ;

Andries, L. ;

Jung, M. ;

Janicot, M. ;

van Emelen, K. .

BRITISH JOURNAL OF CANCER, 2007, 97 (10) :1344-1353

[7] Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity [J].

Auzzas, Luciana ;

Larsson, Andreas ;

Matera, Riccardo ;

Baraldi, Annamaria ;

Deschenes-Simard, Benoit ;

Giannini, Giuseppe ;

Cabri, Walter ;

Battistuzzi, Gianfranco ;

Gallo, Grazia ;

Ciacci, Andrea ;

Vesci, Loredana ;

Pisano, Claudio ;

Hanessian, Stephen .

JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (23) :8387-8399

[8] Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90 - A novel basis for antileukemia activity of histone deacetylase inhibitors [J].

Bali, P ;

Pranpat, M ;

Bradner, J ;

Balasis, M ;

Fiskus, W ;

Guo, F ;

Rocha, K ;

Kumaraswamy, S ;

Boyapalle, S ;

Atadja, P ;

Seto, E ;

Bhalla, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (29) :26729-26734

[9] Ubiquitin Proteasome System Stress Underlies Synergistic Killing of Ovarian Cancer Cells by Bortezomib and a Novel HDAC6 Inhibitor [J].

Bazzaro, Martina ;

Lin, Zhenhua ;

Santillan, Antonio ;

Lee, Michael K. ;

Wang, Mei-Cheng ;

Chan, Kwun C. ;

Bristow, Robert E. ;

Mazitschek, Ralph ;

Bradner, James ;

Roden, Richard B. S. .

CLINICAL CANCER RESEARCH, 2008, 14 (22) :7340-7347

[10] Role of the tetradecapeptide repeat domain of human histone deacetylase 6 in cytoplasmic retention [J].

Bertos, NR ;

Gilquin, B ;

Chan, GKT ;

Yen, TJ ;

Khochbin, S ;

Yang, XJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (46) :48246-48254

← 1 2 3 4 5 6 7 8 9 10 →