Attenuation of the disruptive effects of (+/-)3,4-methylene dioxymethamphetamine (MDMA) on delayed matching-to-sample performance in the rat

被引：20

作者：

Harper, DN ^{[1
]}

Hunt, M ^{[1
]}

Schenk, S ^{[1
]}

机构：

[1] Victoria Univ Wellington, Sch Psychol, Wellington, New Zealand

来源：

BEHAVIORAL NEUROSCIENCE | 2006年 / 120卷 / 01期

关键词：

MDMA; delayed matching-to-sample; memory; proactive interference;

D O I：

10.1037/0735-7044.120.1.201

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Recent evidence suggests that the disruptive effects of acute exposure to (+/-)3,4-methylene dioxymethamphetamine (MDMA) on memory performance may be the result of increased confusion between previous-trial and current-trial events. The current study tested this hypothesis by examining the effects of MDMA on performance of rats in a delayed matching-to-sample procedure when the length of the intertrial interval (ITI) was altered. Consistent with the possibility that limiting the conditions under which responses made on a previous trial would interfere with current-trial choice, a 15-s ITI ameliorated the disruptive effects caused by MDMA on trial performance when the ITI was 5 s. Therefore, the disruptive effects of MDMA on memory can be attenuated by methods that separate current-trial "to-be-remembered" events from previous-trial events.

引用

页码：201 / 205

页数：5

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