Safety, immunogenicity and infectivity of new live attenuated influenza vaccines

被引：30

作者：

Isakova-Sivak, Irina ^{[1
]}

Rudenko, Larisa ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Expt Med, Dept Virol, St Petersburg, Russia

来源：

EXPERT REVIEW OF VACCINES | 2015年 / 14卷 / 10期

基金：

俄罗斯科学基金会;

关键词：

immunogenicity; licensure criteria; live attenuated influenza vaccine; pandemic influenza; safety; seasonal influenza; vaccine virus shedding; PANDEMIC H1N1 INFLUENZA; PHASE-I TRIAL; PROTECTIVE EFFICACY; IMMUNE-RESPONSES; VIRUS-VACCINE; ANTIBODY-RESPONSE; A VIRUSES; T-CELLS; REPLICATION; TRIVALENT;

D O I：

10.1586/14760584.2015.1075883

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Live attenuated influenza vaccines (LAIVs) are believed to be immunologically superior to inactivated influenza vaccines, because they can induce a variety of adaptive immune responses, including serum antibodies, mucosal and cell-mediated immunity. In addition to the licensed cold-adapted LAIV backbones, a number of alternative LAIV approaches are currently being developed and evaluated in preclinical and clinical studies. This review summarizes recent progress in the development and evaluation of LAIVs, with special attention to their safety, immunogenicity and infectivity for humans, and discusses their perspectives for the future.

引用

页码：1313 / 1329

页数：17

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