Erythrocytes as Regulators of Blood Vessel Tone

被引：3

作者：

Luneva, O. G. ^{[1
]}

Sidorenko, S. V. ^{[1
]}

Maksimov, G. V. ^{[1
]}

Grygorczyk, R. ^{[2
]}

Orlov, S. N. ^{[1
,3
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Biol, Moscow 119991, Russia

[2] Univ Montreal, Dept Med, Montreal, PQ H2X 0A9, Canada

[3] Tomsk State Univ, Tomsk 634050, Russia

来源：

BIOLOGICHESKIE MEMBRANY | 2015年 / 32卷 / 04期

关键词：

erythrocytes; hemolysis; oxygen sensor; purinergic signaling system; vessels; INDUCED ATP RELEASE; NITRIC-OXIDE; HYDROGEN-SULFIDE; CYTOPLASMIC DOMAIN; EXTRACELLULAR ATP; OXYGEN DELIVERY; CARBON-MONOXIDE; SIGNALING MECHANISMS; DEPENDENT REGULATION; FLOW REGULATION;

D O I：

10.7868/S0233475515040076

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The drop of oxygen partial pressure results in elevation of the blood vessel diameter. It has been demonstrated that isolated vessels exhibit this unique feature only when they are perfused in the presence of erythrocytes. More recently it was shown that hemoglobin plays a key role in oxygen sensing and its deoxygenated form interacts with band 3 protein, thus triggering the cascade of non-identified intracellular signals involved in nitric oxide production and release of ATP interacting with P2Y purinergic receptors in endothelial cells. In this review, we summarize the data on mechanisms of the ATP release from erythrocytes as well as on its physiological and pathophysiological implications.

引用

页码：223 / 234

页数：12

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