Poly(hydroxyalkanoate)s meet benign solvents for electrospinning

被引：21

作者：

Brunetti, Lucia ^{[1
]}

Degli Esposti, Micaela ^{[1
,2
]}

Morselli, Davide ^{[1
,2
]}

Boccaccini, Aldo R. ^{[3
]}

Fabbri, Paola ^{[1
,2
]}

Liverani, Liliana ^{[3
]}

机构：

[1] Univ Bologna, Dept Civil Chem Environm & Mat Engn, Via Terracini 28, I-40131 Bologna, Italy

[2] Italian Consortium Sci & Technol Mat INSTM, Via Giusti 9, I-50121 Florence, Italy

[3] Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, Cauerstr 6, D-91058 Erlangen, Germany

来源：

MATERIALS LETTERS | 2020年 / 278卷

关键词：

Poly(hydroxyalkanoate)s; Electrospinning; Benign solvents; Bioactive glass; Tissue engineering; NANOFIBERS; COMPOSITE; SCAFFOLDS;

D O I：

10.1016/j.matlet.2020.128389

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Electrospinning (ES) technique allows the fabrication of nano/microfibers, relevant for tissue engineering (TE) applications. Several researches have been devoted to the use of benign solvents for ES, and in this work their use in combination with poly(hydroxyalkanoate)s (PHAs) is reported. Among PHAs, poly(3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and their blend have been selected for their suitability for TE applications. The morphological and chemical properties of the electrospun mats, their degradation behaviour and cytocompatibility have been investigated, obtaining promising results and comparable properties with mats obtained using standard (not benign) solvents. Moreover, the fabrication of composite fibers incorporating bioactive glass (BG) particles is also reported as proof of concept. (C) 2020 Elsevier B.V. All rights reserved.

引用

页数：4

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