Palladium catalysed tandem cyclisation-anion capture. Part 8: Cascade hydrostannylation-cyclisation-anion capture and cascade hydroboration-cyclisation-anion capture on solid phase

被引：14
作者：
Grigg, R [1 ]
MacLachlan, WS
MacPherson, DT
Sridharan, V
Suganthan, S
机构：
[1] Univ Leeds, Sch Chem, Mol Innovat Divers & Automated Synth Ctr MIDAS, Leeds LS2 9JT, W Yorkshire, England
[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England
来源：
TETRAHEDRON | 2001年 / 57卷 / 52期
关键词：
cascade reactions; palladium catalysis; hydrostannylation; hydroboration; Stille coupling; Suzuki coupling; cyclisation;
D O I：
10.1016/S0040-4020(01)01061-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Up to four bonds and five stereocentres are created, in five component processes (five point diversity), utilising resin bound aryl iodides by hydroboration or hydrostannylation of alkynes, followed by cyclisation-anion capture involving Suzuki or Stille reactions. Three small libraries were prepared to validate the chemistry. (C) 2001 Elsevier Science Ltd. All fights reserved.
引用
收藏
页码：10335 / 10345
页数：11
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