Mechanisms of action of antithymocyte globulin: old dogs with new tricks!

被引：15

作者：

Mohty, Mohamad ^{[1
,2
,3
]}

Gaugler, Beatrice ^{[4
]}

机构：

[1] CHU Nantes, Hop Hotel Dieu, Serv Hematol Clin, F-44093 Nantes 01, France

[2] Univ Nantes, Fac Med, Nantes, France

[3] INSERM, UMR 892, Nantes, France

[4] Univ Franche Comte, INSERM, U645, F-25030 Besancon, France

来源：

LEUKEMIA & LYMPHOMA | 2008年 / 49卷 / 09期

关键词：

polyclonal antibodies; T cell depletion; regulatory T cells; dendritic cells; transplantation; immunosuppression;

D O I：

10.1080/10428190802163321

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Understanding the mechanisms underlying immunological tolerance is the key to successful transplantation. Recent findings demonstrate that polyclonal antibodies such as the antithymocyte globulins preparations can provide wide spectrum immunomodulation, suggesting that their use in the immunosuppression therapeutic armamentarium may help in reducing the incidence of organ rejection and improving patients' outcome after hematopoietic stem cell transplantation.

引用

页码：1664 / 1667

页数：4

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