Linking the Microoiota, Chronic Disease, anc the Immune System

被引：177

作者：

Hand, Timothy W. ^{[1
]}

Vujkovic-Cvijin, Ivan ^{[2
]}

Ridaura, Vanessa K. ^{[2
]}

Belkaid, Yasmine ^{[2
,3
]}

机构：

[1] Univ Pittsburgh, Richard King Mellon Inst Pediat Res, Childrens Hosp Pittsburgh, UPMC, Pittsburgh, PA 15224 USA

[2] NIAID, Mucosal Immunol Sect, Parasit Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[3] NIAID, Microbiome Program, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2016年 / 27卷 / 12期

关键词：

GUT MICROBIOTA; INTESTINAL MICROBIOTA; ENVIRONMENTAL ENTEROPATHY; AKKERMANSIA-MUCINIPHILA; PERIODONTAL-DISEASE; COMMENSAL BACTERIA; ESCHERICHIA-COLI; ORAL INFECTION; ADIPOSE-TISSUE; GLOBAL BURDEN;

D O I：

10.1016/j.tem.2016.08.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic inflammatory diseases (CIDs) are the most important causes of mortality in the world today and are on the rise. We now know that immune-driven inflammation is critical in the etiology of these diseases, though the environmental triggers and cellular mechanisms that lead to their development are still mysterious. Many CIDs are associated with significant shifts in the microbiota toward inflammatory configurations, which can affect the host both by inducing local and systemic inflammation and by alterations in microbiota-derived metabolites. This review discusses recent findings suggesting that shifts in the microbiota may contribute to chronic disease via effects on the immune system.

引用

页码：831 / 843

页数：13

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