Anti-anxiety studies on extracts of Passiflora incarnata Linneaus

被引:100
作者
Dhawan, K [1 ]
Kumar, S [1 ]
Sharma, A [1 ]
机构
[1] Panjab Univ, Inst Pharmaceut Sci, Pharmacognosy Div, Chandigarh 160014, India
关键词
Passiflora incarnata Linn; anxiolytic; elevated plus-maze model; column chromatography; flavonoids;
D O I
10.1016/S0378-8741(01)00339-7
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Passiflora incarnata Linn. has been used to cure anxiety and insomnia since time immemorial. Despite the worldwide use of P. incarnata, the pharmacological work on this plant had been inadequate, inconclusive and wage as the earlier reports were unable to infer the mode of action of the plant as well as the phytoconstituents responsible for the much acclaimed anxiolytic and sedative effects of P. incarnata. An attempt has been made to isolate and identify the bioactive phytomoiety of P. incarnata by resorting to bioactivity directed fractionation and chromatographic procedures. A fraction derived from the methanol extract of P. incarnata has been observed to exhibit significant anxiolytic. activity at a dose of 10 mg/kg in mice using elevated plus-maze model of anxiety. This fraction comprises mainly two components which are visible as blue and turquoise colored fluorescent spots at 366 mn of the UV light. The possibility of a phytoconstituent having benzoflavone nucleus as the basic moiety being responsible for the bioactivity of P. incarnata is highly anticipated. (C) 2001 Published by Elsevier Science Ireland Ltd.
引用
收藏
页码:165 / 170
页数:6
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