Therapeutic Potential of Berberine in the Treatment of Glioma: Insights into Its Regulatory Mechanisms

被引：15

作者：

Asemi, Zatollah ^{[1
]}

Behnam, Mohammad ^{[2
]}

Pourattar, Mohammad Ali ^{[3
]}

Mirzaei, Hamed ^{[1
]}

Razavi, Zahra Sadat ^{[4
]}

Tamtaji, Omid Reza ^{[1
]}

机构：

[1] Kashan Univ Med Sci, Inst Basic Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran

[2] FDA, Halal Res Ctr IRI, Tehran, Iran

[3] Iran Univ Med Sci, Dept Radiobiol, Tehran, Iran

[4] Kashan Univ Med Sci, Student Res Comm, Kashan, Iran

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2021年 / 41卷 / 06期

关键词：

Berberine; Glioma; Apoptosis; Autophagy; Cell cycle arrest; CELL-CYCLE ARREST; N-ACETYLTRANSFERASE ACTIVITY; GLIOBLASTOMA T98G CELLS; MALIGNANT GLIOMA; APOPTOSIS PATHWAY; GENE-EXPRESSION; CANCER CELLS; AUTOPHAGY; INHIBITION; DEATH;

D O I：

10.1007/s10571-020-00903-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glioma is known as one of the most common primary intracranial tumors accounting for four-fifths of malignant brain tumors. There are several biological pathways that play a synergistic, pathophysiological role in glioma, including apoptosis, autophagy, oxidative stress, and cell cycle arrest. According to previous rese arches, the drugs used in the treatment of glioma have been associated with significant limitations. Therefore, improved and/or new therapeutic platforms are required. In this regard, multiple flavonoids and alkaloids have been extensively studied in the treatment of glioma. Berberine is a protoberberine alkaloid with wide range of pharmacological activities, applicable to various pathological conditions. Few studies have reported beneficial roles of berberine in glioma. Berberine exerts its pharmacological functions in glioma by controlling different molecular and cellular pathways. We reviewed the existing knowledge supporting the use of berberine in the treatment of glioma and its effects on molecular and cellular mechanisms.

引用

页码：1195 / 1201

页数：7

共 88 条

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