Pseudo-Pelger-Huet anomaly and granulocytic dysplasia associated with human granulocytic anaplasmosis

被引:5
|
作者
Lee, Sunyoung [1 ]
Khankhanian, Pouya [1 ]
Salama, Carlos [1 ]
Brown, Maritza [1 ]
Lieber, Joseph [1 ]
机构
[1] Icahn Sch Med Mt Sinai, Elmhurst Hosp Ctr, Dept Med, Elmhurst, NY 11373 USA
关键词
Human granulocytic anaplasmosis; Pseudo-Pelger-Huet anomaly; Dysplastic granulocytes; Tick-borne disease; MYCOPHENOLATE-MOFETIL; MYELOID-LEUKEMIA; EHRLICHIOSIS; MUTATIONS; APOPTOSIS; NUCLEUS;
D O I
10.1007/s12185-015-1769-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Pseudo-Pelger-HuA << t anomaly (PHA) refers to mono- or bi-lobed granulocytes, reportedly observed in patients with severe infections and inflammation or hematological malignancies including myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Dysplastic changes in granulocytes are typical manifestations in MDS and granulocytic leukemias. Here, we report the unique case of a patient found to have human granulocytic anaplasmosis (HGA), a tick-borne disease caused by Anaplasma phagocytophilum, a Gram-negative coccobacillus. This patient showed striking hematological manifestations including a large number of pseudo-PHA, a severe degree of left shift, and dysplastic granulocytes. These hematological presentations on the peripheral smear all resolved with doxycycline treatment, implying that the changes were most likely reactive manifestations secondary to HGA, rather than underlying hematological malignancies such as MDS or AML.
引用
收藏
页码:129 / 133
页数:5
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