A review on synthesis and biomedical applications of polyglycolic acid

被引：165

作者：

Budak, Kamil ^{[1
,2
]}

Sogut, Oguz ^{[1
,2
]}

Sezer, Umran Aydemir ^{[1
,2
,3
,4
]}

机构：

[1] Suleyman Demirel Univ, Dept Pharmacol Med Med Device, Fac Med, TR-32260 Isparta, Turkey

[2] Suleyman Demirel Univ, Dermocosmet Res & Applicat Lab IDAL, TR-32260 Isparta, Turkey

[3] Suleyman Demirel Univ, Inst Hlth Sci, Dept Regenerat Med, TR-32200 Isparta, Turkey

[4] Suleyman Demirel Univ, Innovat Technol Res & Applicat Ctr, YETEM, TR-32260 Isparta, Turkey

来源：

JOURNAL OF POLYMER RESEARCH | 2020年 / 27卷 / 08期

关键词：

Polyglycolic acid; Synthesis; Glycolic acid; Glycolide; Biomedical applications; MOLECULAR-WEIGHT POLYGLYCOLIDE; RING-OPENING POLYMERIZATION; POLY(GLYCOLIC ACID); BIODEGRADABLE POLYMERS; DRUG-RELEASE; DEGRADING POLYGLYCOLIDE; CLINICAL-APPLICATIONS; MECHANICAL-PROPERTIES; STRENGTH RETENTION; GLYCOLIC ACID;

D O I：

10.1007/s10965-020-02187-1

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(glycolic acid) (PGA) is an essential biopolymer due to its thermal and mechanical properties and biodegradability which provide utility for medical applications and renewable industry. For biomedical applications, production of PGA with high molecular weight is an essential factor to possess adequate mechanical stability. Primary pathways for PGA synthesis are ring-opening polymerization of glycolide (ROP), direct polycondensation of glycolic acid, and solid-state polycondensation of halogen acetates. For PGA synthesis, different systems have been developed with using varying parameters including catalysis, initiators, solvents, and reaction temperature. This review summarizes the different synthesis pathways and physicochemical properties of PGA. Biomedical applications of PGA are also discussed.

引用

页数：19

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