Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography

被引：44
作者：
Yang, Beibei [1 ,2 ,3 ]
Liu, Houmei [2 ,3 ]
Chen, Jia [2 ,3 ]
Guan, Ming [1 ]
Qiu, Hongdeng [1 ,2 ,3 ]
机构：
[1] Xinjiang Normal Univ, Coll Chem & Chem Engn, Lab Pollut Monitoring & Control, Urumqi 830054, Peoples R China
[2] Chinese Acad Sci, Key Lab Chem Northwestern Plant Resources, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China
[3] Chinese Acad Sci, Key Lab Nat Med Gansu Prov, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China
来源：
JOURNAL OF CHROMATOGRAPHY A | 2016年 / 1468卷
基金：
中国国家自然科学基金;
关键词：
Stationary phase; 2-Methylimidazolium-functionalized silica; Mixed-mode separation; Hydrophilic interaction liquid chromatography; Ion exchange chromatography; PERFORMANCE LIQUID-CHROMATOGRAPHY; CONFINED IONIC-LIQUID; REVERSED-PHASE; SEPARATION; SELECTIVITY; COLUMN; HPLC;
D O I：
10.1016/j.chroma.2016.09.021
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In this paper, a novel 2-methylimidazolium-functionalized silica stationary phase was prepared and further used for hydrophilic interaction and anion-exchange mixed-mode chromatography. The stationary phase was characterized by elemental analysis and Fourier transform infrared spectrometry. The chromatographic properties of this stationary phase were investigated by hydrophilic chromatography for the separation of nucleosides, nucleobases, water soluble vitamins, sulfonamides and saccharides, and ion chromatography for the separation of inorganic anions. The effect of acetonitrile content, salt concentration and pH values of the mobile phase on the retention of the stationary phases was also investigated. Compared with 1-methylimidazolium-functionalized silica stationary phase, this new stationary phase demonstrated similar or better separation selectivity. This new column demonstrated good performance and separation selectivity even better than a commercial hydrophilic column. Besides, 2-methylimidazolium-functionalized silica is possible to be modified again and used as a precursor to derivate some new stationary phases from the 3-position nitrogen. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：79 / 85
页数：7
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