The Management of Patients With Stage IIIA Non-Small Cell Lung Cancer With N2 Mediastinal Node Involvement

被引：70

作者：

Martins, Renato G. ^{[1
]}

D'Amico, Thomas A. ^{[2
]}

Loo, Billy W., Jr. ^{[3
]}

Pinder-Schenck, Mary ^{[4
]}

Borghaei, Hossein ^{[5
]}

Chaft, Jamie E. ^{[6
]}

Ganti, Apar Kishor P. ^{[7
]}

Kong, Feng-Ming ^{[8
]}

Kris, Mark G.

Lennes, Inga T. ^{[9
]}

Wood, Douglas E. ^{[1
]}

机构：

[1] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle Canc Care Alliance, Seattle, WA 98109 USA

[2] Duke Canc Inst, Durham, NC USA

[3] Stanford Canc Inst, Stanford, CA USA

[4] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

[5] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

[6] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[7] Nebraska Med Ctr, UNMC Eppley Canc Ctr, VA Nebraska Western Iowa Hlth Care Syst, Omaha, NE USA

[8] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[9] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2012年 / 10卷 / 05期

关键词：

SLOAN-KETTERING EXPERIENCE; INDUCTION CHEMOTHERAPY; PREOPERATIVE CHEMOTHERAPY; EMISSION-TOMOGRAPHY; NEOADJUVANT THERAPY; ENDOBRONCHIAL ULTRASOUND; CONCURRENT CHEMOTHERAPY; SURGICAL RESECTION; OPERATIVE RISK; TERM SURVIVAL;

D O I：

10.6004/jnccn.2012.0062

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with stage IIIA non small cell lung cancer, determined based on involvement of ipsilateral mediastinal lymph nodes, represent the most challenging management problem in this disease. Patients with this stage disease may have very different degrees of lymph node involvement. The pathologic confirmation of this involvement is a key step in the therapeutic decision. The difference in the degree of lymph node compromise has prognostic and treatment implications. Based on multiple considerations, patients can be treated with induction chemotherapy, chemoradiotherapy followed by surgery, or definitive chemoradiotherapy without surgery. Data derived from clinical trials have provided incomplete guidance for physicians and their patients. The best therapeutic plan is achieved through the multidisciplinary cooperation of a team specialized in lung cancer. (JNCCN 2012;10:599-613)

引用

页码：599 / 613

页数：15

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