Drug Allergy Update: Drug Metabolism as a Risk Factor of cutaneous Drug Allergy

被引：2

作者：

Merk, H. F. ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Klin Dermatol & Allergol, Dohlenfeld 8, D-45479 Mulheim, Germany

来源：

ALLERGOLOGIE | 2017年 / 40卷 / 11期

关键词：

INDUCED SKIN RASH; T-CELL-CLONES; EPIDERMAL-KERATINOCYTES; ADVERSE-REACTIONS; LIVER-MICROSOMES; CYSTIC-FIBROSIS; HYPERSENSITIVITY; SULFAMETHOXAZOLE; BIOACTIVATION; NEVIRAPINE;

D O I：

10.5414/ALX1955

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Hapten-/Prohapten- and p-i-mechanisms are described as pathomechanisms to explain sensitization to small molecular weight compounds leading to the precipitation of drug allergic reactions. The influence of xenobiotica metabolism - in particular by cytochrome P450 and transferases - on these reactions is presented taking nevirapine, sulfamethoxazole, allopurinol, and anticonvulsiva as examples. Furthermore, the possible impact on the predictivity of drug allergy as well on diagnostic procedures is discussed. © 2017 Dustri-Verlag Dr. Karl Feistle.

引用

页码：476 / 482

页数：7

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