Cardiovascular effects of methamphetamine in Parkinson's disease patients

被引：8

作者：

Pavese, N

Rimoldi, O

Gerhard, A

Brooks, DJ

Piccini, P

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Div Neurosci, London W12 00N, England

[2] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, MRC,Clin Sci Ctr, London W12 00N, England

来源：

MOVEMENT DISORDERS | 2004年 / 19卷 / 03期

基金：

英国医学研究理事会;

关键词：

Parkinson's disease; methamphetamine; blood pressure; postganglionic sympathetic neurons;

D O I：

10.1002/mds.10651

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cardiovascular responses after intravenous methamphetamine were assessed in 11 Parkinson's disease (PD) patients. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and electrocardiogram (ECG) were monitored for 103 minutes. After methamphetamine administration, SBP and DBP increased significantly in both PD and normal controls whereas placebo had no effect. In PD patients, however, the duration of SBP and DBP responses to methamphetamine and the maximum increase from baseline was attenuated compared with the controls. A significant correlation was found between individual BP responsiveness and the Unified Parkinson's Disease Rating Scale (UPDRS) motor score. These findings suggest that in PD there is impairment of catecholamine release from peripheral sympathetic presynaptic terminals, which correlates with motor impairment. (C) 2003 Movement Disorder Society.

引用

页码：298 / 303

页数：6

共 37 条

[1] Cardiovascular effects of 0.5 milligrams per kilogram oral d-amphetamine and possible attenuation by haloperidol [J].

Angrist, B ;

Sanfilipo, M ;

Wolkin, A .

CLINICAL NEUROPHARMACOLOGY, 2001, 24 (03) :139-144

[2] DEFECTIVE CARDIOVASCULAR REFLEXES AND SUPER-SENSITIVITY TO SYMPATHOMIMETIC DRUGS IN AUTONOMIC FAILURE [J].

BANNISTER, R ;

DAVIES, B ;

HOLLY, E ;

ROSENTHAL, T ;

SEVER, P .

BRAIN, 1979, 102 (MAR) :163-176

[3] Impaired cardiac uptake of meta[123I]iodobenzylguanidine in Parkinson's disease with autonomic failure [J].

Braune, S ;

Reinhardt, M ;

Bathmann, J ;

Krause, T ;

Lehmann, M ;

Lucking, CH .

ACTA NEUROLOGICA SCANDINAVICA, 1998, 97 (05) :307-314

[4] Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method [J].

Breier, A ;

Su, TP ;

Saunders, R ;

Carson, RE ;

Kolachana, BS ;

de Bartolomeis, A ;

Weinberger, DR ;

Weisenfeld, N ;

Malhotra, AK ;

Eckelman, WC ;

Pickar, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) :2569-2574

[5] Quantification of amphetamine-induced changes in [C-11]raclopride binding with continuous infusion [J].

Carson, RE ;

Breier, A ;

deBartolomeis, A ;

Saunders, RC ;

Su, TP ;

Schmall, B ;

Der, MG ;

Pickar, D ;

Eckelman, WC .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1997, 17 (04) :437-447

[6] ICE - A NEW DOSAGE FORM OF AN OLD DRUG [J].

CHO, AK .

SCIENCE, 1990, 249 (4969) :631-634

[7] Central mechanisms underlying short- and long-term regulation of the cardiovascular system [J].

Dampney, RAL ;

Coleman, MJ ;

Fontes, MAP ;

Hirooka, Y ;

Horiuchi, J ;

Li, YW ;

Polson, JW ;

Potts, PD ;

Tagawa, T .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2002, 29 (04) :261-268

[8]

Daniel S E, 1993, J Neural Transm Suppl, V39, P165

[9] Differentiation of Parkinson's disease and multiple system atrophy in early disease stages by means of I-123-MIBG-SPECT [J].

Druschky, A ;

Hilz, MJ ;

Platsch, G ;

Radespiel-Tröger, M ;

Druschky, K ;

Kuwert, T ;

Neundörfer, B .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2000, 175 (01) :3-12

[10]

Fahn S., 1987, RECENT DEV PARKINSON, V2

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