Increased production of interleukin-10 in children with Down syndrome upon ex vivo stimulation with Streptococcus pneumoniae

被引:10
作者
Broers, Chantal J. M. [1 ]
Gemke, Reinoud J. B. J. [1 ]
Morre, Servaas A. [2 ,3 ]
Weijerman, Michel E. [1 ]
van Furth, Anne Marceline [4 ]
机构
[1] Vrije Univ Amsterdam, Med Ctr, Dept Pediat, Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Med Ctr, Dept Med Microbiol & Infect Control, Immunogenet Lab, Amsterdam, Netherlands
[3] Univ Maastricht, Fac Hlth Med & Life Sci, Res Inst GROW, Inst Publ Hlth Genom,Dept Genet & Cell Biol, Maastricht, Netherlands
[4] Vrije Univ Amsterdam, Med Ctr, Dept Pediat Infect Dis Immunol & Rheumatol, Amsterdam, Netherlands
关键词
COMMUNITY-ACQUIRED PNEUMONIA; RESPIRATORY-TRACT INFECTIONS; SYSTEMIC CYTOKINE RESPONSE; INTRINSIC DEFECT; PNEUMOCOCCAL PNEUMONIA; IMMUNE-SYSTEM; VIRUS; IMMUNODEFICIENCY; PREVALENCE; TRISOMY-21;
D O I
10.1038/pr.2013.173
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
BACKGROUND: Children with Down syndrome (DS) have an increased susceptibility to infections, due to altered humoral and/or cellular immunity. The aim of the study was to determine the cytokine production in whole blood of children with DS upon stimulation with heat-killed Streptococcus pneumoniae and lipopolysaccharide (LPS), in comparison with their healthy siblings. METHODS: Whole blood of 61 children with DS and 57 of their healthy siblings was stimulated with 200 ng/ml LPS and 4x10(7) colony-forming units/ml S. pneumoniae during 6, 24, and 48 h. Concentrations of pro- and anti-inflammatory cytokines, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6, IL-8, IL-12p70, and IL-10 were determined at all time points. RESULTS: Children with DS show an increased IL-10 production upon stimulation with S. pneumoniae compared to their healthy siblings. At most time points, no significant differences were seen in cytokine production upon stimulation with LPS. CONCLUSION: Children with DS may be prone to a severe course of pneumococcal pneumonia, because of an increased anti-inflammatory response.
引用
收藏
页码:109 / 113
页数:5
相关论文
共 45 条
[1]   ABNORMAL SERUM IGG SUBCLASS PATTERN IN CHILDREN WITH DOWNS-SYNDROME [J].
ANNEREN, G ;
MAGNUSSON, CGM ;
LILJA, G ;
NORDVALL, SL .
ARCHIVES OF DISEASE IN CHILDHOOD, 1992, 67 (05) :628-631
[2]  
AVANZINI MA, 1990, AM J MED GENET, P231
[3]   Down syndrome: A novel risk factor for respiratory syncytial virus bronchiolitis - A prospective birth-cohort study [J].
Bloemers, Beatrijs L. P. ;
van Furth, Marceline ;
Weijerman, Michel E. ;
Gemke, Reinoud J. B. J. ;
Broers, Chantal J. M. ;
van den Ende, Kimberly ;
Kimpen, Jan L. L. ;
Strengers, Jan L. M. ;
Bont, Louis J. .
PEDIATRICS, 2007, 120 (04) :E1076-e1081
[4]   Increased risk of respiratory tract infections in children with Down syndrome: the consequence of an altered immune system [J].
Bloemers, Beatrijs L. P. ;
Broers, Chantal J. M. ;
Bont, Louis ;
Weijerman, Michel E. ;
Gemke, Reinoud J. B. J. ;
van Furth, A. Marceline .
MICROBES AND INFECTION, 2010, 12 (11) :799-808
[5]   Distinct Abnormalities in the Innate Immune System of Children with Down Syndrome [J].
Bloemers, Beatrijs L. P. ;
van Bleek, Grada M. ;
Kimpen, Jan L. L. ;
Bont, Louis .
JOURNAL OF PEDIATRICS, 2010, 156 (05) :804-U162
[6]   The systemic inflammatory response in the development of ventilator-associated pneumonia [J].
Bonten, MJM ;
Froon, AHM ;
Gaillard, CA ;
Greve, JWM ;
deLeeuw, PW ;
Drent, M ;
Stobberingh, EE ;
Buurman, WA .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 156 (04) :1105-1113
[7]   Frequency of lower respiratory tract infections in relation to adaptive immunity in children with Down syndrome compared to their healthy siblings [J].
Broers, Chantal J. M. ;
Gemke, Reinoud J. B. J. ;
Weijerman, Michel E. ;
Kuik, Dirk-J ;
van Hoogstraten, Ingrid M. W. ;
van Furth, A. Marceline .
ACTA PAEDIATRICA, 2012, 101 (08) :862-867
[8]   Increased Pro-inflammatory Cytokine Production in Down syndrome Children Upon Stimulation with Live Influenza A Virus [J].
Broers, Chantal J. M. ;
Gemke, Reinoud J. B. J. ;
Weijerman, Michel E. ;
van der Sluijs, Koen F. ;
van Furth, A. Marceline .
JOURNAL OF CLINICAL IMMUNOLOGY, 2012, 32 (02) :323-329
[9]   Proinflammatory cytokines, fibrinolytic system enzymes, and biochemical indices in children with infectious para-pneumonic effusions [J].
Chiu, Chih-Yung ;
Wong, Kin-Sun ;
Huang, Jing-Long ;
Tasi, Ming-Han ;
Lin, Tzou-Yien ;
Hsieh, Sen-Yung .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2008, 27 (08) :699-703
[10]  
COSSARIZZA A, 1990, AM J MED GENET, P213