Low-pH-induced fusion of Vero cells infected with Junin virus

被引：30
作者：
Castilla, V
Mersich, SE
机构：
[1] Laboratorio de Virología, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires
[2] Laboratorio de Virología, Depto. Quim. Biológica, Pabellón 2
来源：
ARCHIVES OF VIROLOGY | 1996年 / 141卷 / 07期
关键词：
D O I：
10.1007/BF01718832
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Junin virus (JV) infected Vero cells were used to investigate virus capacity to induce cell-cell fusion. Polykaryocyte formation due to JV was found to be pH and temperature-dependent. A reduced fusion activity was detected on BHK-21 cells. Different JV-strains exhibited a similar extent and pH dependence of their fusion activity. Neutralizing antibodies against the main viral glycoprotein (GP38) inhibited syncytium production and GP38 conformational changes in response to acid treatment were detected by an immunoprecipitation assay.
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页码：1307 / 1317
页数：11
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