Fusobacterium nucleatum and adverse pregnancy outcomes: Epidemiological and mechanistic evidence

被引：86

作者：

Vander Haar, Emilie L. ^{[1
]}

So, Jeewon ^{[2
]}

Gyamfi-Bannerman, Cynthia ^{[1
]}

Han, Yiping W. ^{[3
,4
,5
,6
]}

机构：

[1] Columbia Univ, Dept Obstet & Gynecol, Med Ctr, Div Maternal Fetal Med, New York, NY USA

[2] Columbia Univ Coll Phys & Surg, Med Ctr, Inst Human Nutr, 630 W 168th St, New York, NY 10032 USA

[3] Columbia Univ, Div Periodont, Coll Dent Med, Med Ctr, New York, NY USA

[4] Columbia Univ Coll Phys & Surg, Dept Microbiol & Immunol, Med Ctr, 630 W 168th St, New York, NY 10032 USA

[5] Columbia Univ Coll Phys & Surg, Dept Obstet & Gynecol, Med Ctr, New York, NY 10032 USA

[6] Columbia Univ Coll Phys & Surg, Dept Med, Med Ctr, New York, NY USA

来源：

ANAEROBE | 2018年 / 50卷

关键词：

Oral anaerobe; Pregnancy complications; Preterm birth; Stillbirth; Neonatal sepsis; VE-cadherin; Placenta; Chorioamnionitis; Fusobacterium nucleatum; FadA; FLUID INTERLEUKIN-6 LEVELS; PRETERM BIRTH; ORAL BACTERIA; PERIODONTAL-DISEASE; AMNIOTIC-FLUID; INTRAAMNIOTIC INFECTION; INTRAUTERINE INFECTION; FETAL MEMBRANES; DELIVERY; ADHESIN;

D O I：

10.1016/j.anaerobe.2018.01.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fusobacterium nucleatum is a Gram-negative anaerobic oral commensal associated with periodontal disease. F. nucleatum has been implicated in a wide spectrum of systemic diseases, including oral, gastrointestinal, rheumatologic, and vascular pathologies. As pregnancy risk has been linked to periodontal disease, there has also been significant research into the effects of periodontal disease on adverse pregnancy outcomes. This article reviews the epidemiological and mechanistic evidence of the role of F. nucleatum in adverse pregnancy outcomes. (C) 2018 The Authors. Published by Elsevier Ltd.

引用

页码：55 / 59

页数：5

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