共 60 条
H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction
被引:136
作者:

Taylor, Gillian C. A.
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Univ Edinburgh, MRC Human Genet Unit, MRC Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh, MRC Human Genet Unit, MRC Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland

Eskeland, Ragnhild
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机构:
Univ Edinburgh, MRC Human Genet Unit, MRC Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh, MRC Human Genet Unit, MRC Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland

Hekimoglu-Balkan, Betuel
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h-index: 0
机构:
Univ Edinburgh, MRC Human Genet Unit, MRC Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh, MRC Human Genet Unit, MRC Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland

Pradeepa, Madapura M.
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机构:
Univ Edinburgh, MRC Human Genet Unit, MRC Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh, MRC Human Genet Unit, MRC Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland

Bickmore, Wendy A.
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h-index: 0
机构:
Univ Edinburgh, MRC Human Genet Unit, MRC Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh, MRC Human Genet Unit, MRC Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
机构:
[1] Univ Edinburgh, MRC Human Genet Unit, MRC Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
基金:
英国医学研究理事会;
关键词:
DROSOPHILA MSL COMPLEX;
H4 TAIL ACETYLATIONS;
MALE X-CHROMOSOME;
HISTONE H4;
DOSAGE COMPENSATION;
NUCLEAR REORGANIZATION;
H4-K16;
ACETYLATION;
KEY REGULATOR;
MOF;
DISTINCT;
D O I:
10.1101/gr.155028.113
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Compared with histone H3, acetylation of H4 tails has not been well studied, especially in mammalian cells. Yet, H4K16 acetylation is of particular interest because of its ability to decompact nucleosomes in vitro and its involvement in dosage compensation in flies. Here we show that, surprisingly, loss of H4K16 acetylation does not alter higher-order chromatin compaction in vivo in mouse embryonic stem cells (ESCs). As well as peaks of acetylated H4K16 and KAT8 histone acetyltransferase at the transcription start sites of expressed genes, we report that acetylation of H4K16 is a new marker of active enhancers in ESCs and that some enhancers are marked by H3K4me1, KAT8, and H4K16ac, but not by acetylated H3K27 or EP300, suggesting that they are novel EP300 independent regulatory elements. Our data suggest a broad role for different histone acetylation marks and for different histone acetyltransferases in long-range gene regulation.
引用
收藏
页码:2053 / 2065
页数:13
相关论文
共 60 条
[51]
HMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells
[J].
Taipale, M
;
Rea, S
;
Richter, K
;
Vilar, A
;
Lichter, P
;
Imhof, A
;
Akhtar, A
.
MOLECULAR AND CELLULAR BIOLOGY,
2005, 25 (15)
:6798-6810

Taipale, M
论文数: 0 引用数: 0
h-index: 0
机构: European Mol Biol Lab, Gene Express Programme, D-69117 Heidelberg, Germany

Rea, S
论文数: 0 引用数: 0
h-index: 0
机构: European Mol Biol Lab, Gene Express Programme, D-69117 Heidelberg, Germany

Richter, K
论文数: 0 引用数: 0
h-index: 0
机构: European Mol Biol Lab, Gene Express Programme, D-69117 Heidelberg, Germany

Vilar, A
论文数: 0 引用数: 0
h-index: 0
机构: European Mol Biol Lab, Gene Express Programme, D-69117 Heidelberg, Germany

Lichter, P
论文数: 0 引用数: 0
h-index: 0
机构: European Mol Biol Lab, Gene Express Programme, D-69117 Heidelberg, Germany

Imhof, A
论文数: 0 引用数: 0
h-index: 0
机构: European Mol Biol Lab, Gene Express Programme, D-69117 Heidelberg, Germany

Akhtar, A
论文数: 0 引用数: 0
h-index: 0
机构: European Mol Biol Lab, Gene Express Programme, D-69117 Heidelberg, Germany
[52]
Mof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture
[J].
Thomas, Tim
;
Dixon, Mathew P.
;
Kueh, Andrew J.
;
Voss, Anne K.
.
MOLECULAR AND CELLULAR BIOLOGY,
2008, 28 (16)
:5093-5105

Thomas, Tim
论文数: 0 引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
Univ Melbourne, Dept Med Biol, Parkville, Vic 3050, Australia Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

Dixon, Mathew P.
论文数: 0 引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

Kueh, Andrew J.
论文数: 0 引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
Univ Melbourne, Dept Med Biol, Parkville, Vic 3050, Australia Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

论文数: 引用数:
h-index:
机构:
[53]
Regulation of Transcription through Acetylation of H3K122 on the Lateral Surface of the Histone Octamer
[J].
Tropberger, Philipp
;
Pott, Sebastian
;
Keller, Claudia
;
Kamieniarz-Gdula, Kinga
;
Caron, Matthieu
;
Richter, Florian
;
Li, Guohong
;
Mittler, Gerhard
;
Liu, Edison T.
;
Buehler, Marc
;
Margueron, Raphael
;
Schneider, Robert
.
CELL,
2013, 152 (04)
:859-872

Tropberger, Philipp
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany
Univ Strasbourg, INSERM,U964, CNRS UMR 7104, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany

Pott, Sebastian
论文数: 0 引用数: 0
h-index: 0
机构:
Genome Inst Singapore, Singapore 138672, Singapore Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany

Keller, Claudia
论文数: 0 引用数: 0
h-index: 0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Univ Basel, CH-4003 Basel, Switzerland Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany

Kamieniarz-Gdula, Kinga
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany

Caron, Matthieu
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Curie, F-75005 Paris, France
CNRS, UMR 3215, F-75005 Paris, France
INSERM, U934, F-75005 Paris, France Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany

Richter, Florian
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany

Li, Guohong
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany

Mittler, Gerhard
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany

Liu, Edison T.
论文数: 0 引用数: 0
h-index: 0
机构:
Genome Inst Singapore, Singapore 138672, Singapore Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany

Buehler, Marc
论文数: 0 引用数: 0
h-index: 0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Univ Basel, CH-4003 Basel, Switzerland
INSERM, U934, F-75005 Paris, France Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany

Margueron, Raphael
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Curie, F-75005 Paris, France
CNRS, UMR 3215, F-75005 Paris, France Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany

Schneider, Robert
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany
Univ Strasbourg, INSERM,U964, CNRS UMR 7104, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany
[54]
Combinatorial patterns of histone acetylations and methylations in the human genome
[J].
Wang, Zhibin
;
Zang, Chongzhi
;
Rosenfeld, Jeffrey A.
;
Schones, Dustin E.
;
Barski, Artem
;
Cuddapah, Suresh
;
Cui, Kairong
;
Roh, Tae-Young
;
Peng, Weiqun
;
Zhang, Michael Q.
;
Zhao, Keji
.
NATURE GENETICS,
2008, 40 (07)
:897-903

Wang, Zhibin
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA

Zang, Chongzhi
论文数: 0 引用数: 0
h-index: 0
机构:
George Washington Univ, Dept Phys, Washington, DC 20052 USA NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA

Rosenfeld, Jeffrey A.
论文数: 0 引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA

Schones, Dustin E.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA

Barski, Artem
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA

Cuddapah, Suresh
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA

Cui, Kairong
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA

Roh, Tae-Young
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA

Peng, Weiqun
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA

Zhang, Michael Q.
论文数: 0 引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA

Zhao, Keji
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA
[55]
Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes
[J].
Wang, Zhibin
;
Zang, Chongzhi
;
Cui, Kairong
;
Schones, Dustin E.
;
Barski, Artem
;
Peng, Weiqun
;
Zhao, Keji
.
CELL,
2009, 138 (05)
:1019-1031

Wang, Zhibin
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Zang, Chongzhi
论文数: 0 引用数: 0
h-index: 0
机构:
George Washington Univ, Dept Phys, Washington, DC 20052 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Cui, Kairong
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Schones, Dustin E.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Barski, Artem
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Peng, Weiqun
论文数: 0 引用数: 0
h-index: 0
机构:
George Washington Univ, Dept Phys, Washington, DC 20052 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Zhao, Keji
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA
[56]
The RING Finger Protein MSL2 in the MOF Complex Is an E3 Ubiquitin Ligase for H2B K34 and Is Involved in Crosstalk with H3 K4 and K79 Methylation
[J].
Wu, Lipeng
;
Zee, Barry M.
;
Wang, Yanming
;
Garcia, Benjamin A.
;
Dou, Yali
.
MOLECULAR CELL,
2011, 43 (01)
:132-144

Wu, Lipeng
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

Zee, Barry M.
论文数: 0 引用数: 0
h-index: 0
机构:
Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

Wang, Yanming
论文数: 0 引用数: 0
h-index: 0
机构:
Penn State Univ, Dept Biochem, University Pk, PA 16802 USA Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

Garcia, Benjamin A.
论文数: 0 引用数: 0
h-index: 0
机构:
Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

Dou, Yali
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA
[57]
WDR5 associates with histone H3 methylated at K4 and is essential for H3K4 methylation and vertebrate development
[J].
Wysocka, J
;
Swigut, T
;
Milne, TA
;
Dou, YL
;
Zhang, X
;
Burlingame, AL
;
Roeder, RG
;
Brivanlou, AH
;
Allis, CD
.
CELL,
2005, 121 (06)
:859-872

Wysocka, J
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Chromatin Biol, New York, NY 10021 USA

Swigut, T
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Chromatin Biol, New York, NY 10021 USA

Milne, TA
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Chromatin Biol, New York, NY 10021 USA

Dou, YL
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Chromatin Biol, New York, NY 10021 USA

Zhang, X
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Chromatin Biol, New York, NY 10021 USA

Burlingame, AL
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Chromatin Biol, New York, NY 10021 USA

Roeder, RG
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Chromatin Biol, New York, NY 10021 USA

Brivanlou, AH
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Chromatin Biol, New York, NY 10021 USA

Allis, CD
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Lab Chromatin Biol, New York, NY 10021 USA Rockefeller Univ, Lab Chromatin Biol, New York, NY 10021 USA
[58]
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
[J].
Ying, QL
;
Stavridis, M
;
Griffiths, D
;
Li, M
;
Smith, A
.
NATURE BIOTECHNOLOGY,
2003, 21 (02)
:183-186

Ying, QL
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Edinburgh, Inst Stem Cell Res, Edinburgh EH9 3JQ, Midlothian, Scotland Univ Edinburgh, Inst Stem Cell Res, Edinburgh EH9 3JQ, Midlothian, Scotland

论文数: 引用数:
h-index:
机构:

Griffiths, D
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Edinburgh, Inst Stem Cell Res, Edinburgh EH9 3JQ, Midlothian, Scotland Univ Edinburgh, Inst Stem Cell Res, Edinburgh EH9 3JQ, Midlothian, Scotland

Li, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Edinburgh, Inst Stem Cell Res, Edinburgh EH9 3JQ, Midlothian, Scotland Univ Edinburgh, Inst Stem Cell Res, Edinburgh EH9 3JQ, Midlothian, Scotland

Smith, A
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Edinburgh, Inst Stem Cell Res, Edinburgh EH9 3JQ, Midlothian, Scotland Univ Edinburgh, Inst Stem Cell Res, Edinburgh EH9 3JQ, Midlothian, Scotland
[59]
A clustering approach for identification of enriched domains from histone modification ChIP-Seq data
[J].
Zang, Chongzhi
;
Schones, Dustin E.
;
Zeng, Chen
;
Cui, Kairong
;
Zhao, Keji
;
Peng, Weiqun
.
BIOINFORMATICS,
2009, 25 (15)
:1952-1958

Zang, Chongzhi
论文数: 0 引用数: 0
h-index: 0
机构:
George Washington Univ, Dept Phys, Washington, DC 20052 USA George Washington Univ, Dept Phys, Washington, DC 20052 USA

Schones, Dustin E.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA George Washington Univ, Dept Phys, Washington, DC 20052 USA

Zeng, Chen
论文数: 0 引用数: 0
h-index: 0
机构:
George Washington Univ, Dept Phys, Washington, DC 20052 USA George Washington Univ, Dept Phys, Washington, DC 20052 USA

Cui, Kairong
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA George Washington Univ, Dept Phys, Washington, DC 20052 USA

Zhao, Keji
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA George Washington Univ, Dept Phys, Washington, DC 20052 USA

Peng, Weiqun
论文数: 0 引用数: 0
h-index: 0
机构:
George Washington Univ, Dept Phys, Washington, DC 20052 USA George Washington Univ, Dept Phys, Washington, DC 20052 USA
[60]
Critical Roles of Coactivator p300 in Mouse Embryonic Stem Cell Differentiation and Nanog Expression
[J].
Zhong, Xiaomin
;
Jin, Ying
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2009, 284 (14)
:9168-9175

Zhong, Xiaomin
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Jiao Tong Univ, Shanghai Inst Biol Sci,Sch Med, Key Lab Stem Cell Biol,Inst Hlth Sci, Beijing 100000, Peoples R China
Chinese Acad Sci, Grad Sch, Beijing 100000, Peoples R China Chinese Acad Sci, Shanghai Jiao Tong Univ, Shanghai Inst Biol Sci,Sch Med, Key Lab Stem Cell Biol,Inst Hlth Sci, Beijing 100000, Peoples R China

Jin, Ying
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Jiao Tong Univ, Shanghai Inst Biol Sci,Sch Med, Key Lab Stem Cell Biol,Inst Hlth Sci, Beijing 100000, Peoples R China
Shanghai Jiao Tong Univ, Sch Med, Shanghai Stem Cell Inst, Beijing 100000, Peoples R China Chinese Acad Sci, Shanghai Jiao Tong Univ, Shanghai Inst Biol Sci,Sch Med, Key Lab Stem Cell Biol,Inst Hlth Sci, Beijing 100000, Peoples R China