eInterleukin newcomers creating new numbers in rheumatology: IL-34 to IL-38

被引:49
作者
Clavel, Gaelle [1 ,2 ]
Thiolat, Allan [1 ]
Boissier, Marie-Christophe [1 ,3 ]
机构
[1] Univ Paris 13, Sorbonne Paris Cite, Li2P, EA4222, Bobigny, France
[2] Fdn Adolphe De Rothschild, Serv Med Interne, F-75940 Paris 19, France
[3] Grp Hosp Avicenne Jean Verdier Rene Muret, AP HP, Serv Rhumatol, Bobigny, France
关键词
IL-34; IL-35; IL-36; IL-37; IL-38; Interleukins; Rheumatoid arthritis; REGULATORY T-CELLS; ANTIINFLAMMATORY CYTOKINE; INDUCED ARTHRITIS; IMMUNE-RESPONSES; GENE-CLUSTER; INTERLEUKIN-34; SUPPRESSION; RECEPTOR; LIGANDS; EXPRESSION;
D O I
10.1016/j.jbspin.2013.04.014
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The development of innovative technologies is steadily increasing the body of knowledge on molecules involved in physiological functions. Thus, several interleukins (ILs) have been identified and characterized in the past few years. Here, we detail the structural and functional characteristics of IL-34 to IL-38 with special attention to their involvement in inflammatory joint disease. IL-34 chiefly increases osteoclast activation and proliferation and therefore, it plays a direct role in bone destruction as seen in rheumatoid arthritis (RA). Regulatory T-cells (Tregs) express IL-35, which therefore exerts antiinflammatory effects by restoring Treg suppressive capabilities and by inhibiting the Th17 pathway. IL-37 has anti-inflammatory effects mediated by a negative feedback loop that decreases the release of pro-inflammatory cytokines. IL-36 belongs to the IL-1 family and has three different forms. Although this cytokine has been chiefly studied in psoriasis and psoriatic arthritis, it also exerts pro-inflammatory effects in RA. The specific IL-36 antagonist, IL-36Ra binds to the IL-36 receptor, thereby, preventing signal transduction. Finally, IL-38 is a recently identified cytokine whose effect may resemble that of IL-36Ra as it binds to the IL-36 receptor and inhibits its effects, particularly the Thl 7-response. Although the exact roles for these cytokines awaits elucidation, the current improvements in our knowledge of the mechanisms that regulate chronic inflammatory conditions, such as RA may lead to the identification of new treatment targets. (C) 2013 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:449 / 453
页数:5
相关论文
共 51 条
[1]   Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3 [J].
Allan, Sarah E. ;
Song-Zhao, George X. ;
Abraham, Thomas ;
McMurchy, Alicia N. ;
Levings, Megan K. .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (12) :3282-3289
[2]   A Cytokine-Centric View of the Pathogenesis and Treatment of Autoimmune Arthritis [J].
Astry, Brian ;
Harberts, Erin ;
Moudgil, Kamal D. .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2011, 31 (12) :927-940
[3]   From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines [J].
Banchereau, Jacques ;
Pascual, Virginia ;
O'Garra, Anne .
NATURE IMMUNOLOGY, 2012, 13 (10) :925-931
[4]   Human CD4+CD25+Foxp3+ Regulatory T Cells Do Not Constitutively Express IL-35 [J].
Bardel, Emilie ;
Larousserie, Frederique ;
Charlot-Rabiega, Pascaline ;
Coulomb-L'Hermine, Aurore ;
Devergne, Odile .
JOURNAL OF IMMUNOLOGY, 2008, 181 (10) :6898-6905
[5]   Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis [J].
Baud'Huin, Marc ;
Renault, Romain ;
Charrier, Celine ;
Riet, Anne ;
Moreau, Anne ;
Brion, Regis ;
Gouin, Francois ;
Duplomb, Laurence ;
Heymann, Dominique .
JOURNAL OF PATHOLOGY, 2010, 221 (01) :77-86
[6]   Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14 [J].
Bensen, JT ;
Dawson, PA ;
Mychaleckyj, JC ;
Bowden, DW .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2001, 21 (11) :899-904
[7]   Regulatory T cells and inhibitory cytokines in autoimmunity [J].
Bettini, Maria ;
Vignali, Dario A. A. .
CURRENT OPINION IN IMMUNOLOGY, 2009, 21 (06) :612-618
[8]   Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation [J].
Blumberg, Hal ;
Dinh, Huyen ;
Trueblood, Esther S. ;
Pretorius, James ;
Kugler, David ;
Weng, Ning ;
Kanaly, Suzanne T. ;
Towne, Jennifer E. ;
Willis, Cynthia R. ;
Kuechle, Melanie K. ;
Sims, John E. ;
Peschon, Jacques J. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (11) :2603-2614
[9]   IL-1RL2 and Its Ligands Contribute to the Cytokine Network in Psoriasis [J].
Blumberg, Hal ;
Dinh, Huyen ;
Dean, Charles, Jr. ;
Trueblood, Esther S. ;
Bailey, Keith ;
Shows, Donna ;
Bhagavathula, Narasimharao ;
Aslam, Muhammad Nadeem ;
Varani, James ;
Towne, Jennifer E. ;
Sims, John E. .
JOURNAL OF IMMUNOLOGY, 2010, 185 (07) :4354-4362
[10]   Cell and cytokine imbalances in rheumatoid synovitis [J].
Boissier, Marie-Christophe .
JOINT BONE SPINE, 2011, 78 (03) :230-234